Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
33 authors.
Shahrzad EzzatpourDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-9688-2375
Khushabu ThakurAdvanced Science Research Center at The Graduate Center of the City University of New York 85 St Nicholas Terrace, New York, NY 10031 USA.ORCID 0000-0002-6498-7487
Kenneth Erzoah NdedeAdvanced Science Research Center at The Graduate Center of the City University of New York 85 St Nicholas Terrace, New York, NY 10031 USA.ORCID 0009-0008-4089-8456
David W BuchholzDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-8874-6648
Annette ChoiDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0002-9537-5037
Brian ImbiakhaDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-8538-5445
Jordan CarterDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0009-0008-9679-4285
David OnofreiDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182 USA.ORCID 0000-0002-6386-0716
Brett EatonNational Institute of Allergy and Infectious Diseases Integrated Research Facility, Ft. Detrick, Frederick, MD 21702 USA.ORCID 0000-0002-3060-2913
Elena PostnikovaNational Institute of Allergy and Infectious Diseases Integrated Research Facility, Ft. Detrick, Frederick, MD 21702 USA.ORCID 0000-0002-0275-2148
Michael MurphyNational Institute of Allergy and Infectious Diseases Integrated Research Facility, Ft. Detrick, Frederick, MD 21702 USA.
Beicer C TapiaDepartment of Chemistry and Biochemistry, Hunter College, 695 Park Ave., New York, NY 10065 USA.ORCID 0000-0001-5157-3798
Diana BelloDepartment of Chemistry and Biochemistry, Hunter College, 695 Park Ave., New York, NY 10065 USA.
Siddharth PasariHunter High School, 71 East 94th Street, New York, NY 10128, USA.ORCID 0009-0005-0497-5643
Anthony RussoHunter High School, 71 East 94th Street, New York, NY 10128, USA.ORCID 0009-0005-3105-9958
Matthew BabayevSophie Davis Biomedical Education Program at the CUNY School of Medicine, 160 Convent Ave., New York, NY 10031 USA.
Gregory P HollandDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182 USA.ORCID 0000-0003-3062-3391
Michael R HolbrookNational Institute of Allergy and Infectious Diseases Integrated Research Facility, Ft. Detrick, Frederick, MD 21702 USA.ORCID 0000-0002-0824-2667
Sara L CaddyBaker Institute for Animal Health, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0002-9790-7420
Steven J MoranBaker Institute for Animal Health, Cornell University, Ithaca, NY 14850, USA.
Seyed Mohammad DavachiDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, United States.ORCID 0000-0001-7002-3708
Isaac Abrrey MonrealDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0003-0521-9063
Julie SahlerDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0003-1852-9511
Victoria OrtegaDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0002-6374-6796
Jose M MirandaDepartment of Analytical Chemistry, Nutrition and Food Science, School of Veterinary Sciences, Universidade de Santiago de Compostela, Pabellon 4, Planta Baja, 27002 Lugo, Spain.ORCID 0000-0001-7992-1491
Gary R WhittakerDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-8037-3816
Mason C JagerDepartment of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-6036-9895
Seema K BhagwatComplex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd., Athens, GA 30602, USA.
Pradeep ChopraComplex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd., Athens, GA 30602, USA.ORCID 0000-0002-6003-4574
Geert Jan-BoonsComplex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd., Athens, GA 30602, USA.ORCID 0000-0003-3111-5954
Mateusz MarianskiDepartment of Chemistry and Biochemistry, Hunter College, 695 Park Ave., New York, NY 10065 USA.ORCID 0000-0002-6566-9931
Adam B BraunschweigAdvanced Science Research Center at The Graduate Center of the City University of New York 85 St Nicholas Terrace, New York, NY 10031 USA.ORCID 0000-0003-0344-3029
Hector C AguilarDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-6879-8360
Funding
Mechanisms of Nipah virus fusion and entryR01AI109022 · NIAID · WASHINGTON STATE UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2014 to 2024
$4.3M
Automated chemo-enzymatic synthesis of N-glycans for host-pathogen interactionsR01AI165692 · NIAID · UNIVERSITY OF GEORGIA · PI BOONS, GEERT-JAN · 2022 to 2025
$2.2M
Hopping Sugars: molecular mechanism of protonatedglycans rearrangementSC2GM135145 · NIGMS · HUNTER COLLEGE · PI MARIANSKI, MATEUSZ RYSZARD · 2020 to 2022
Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-CoV, EBOV, MARV, NiV, and HeV. Notably,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families. · full record | OpenQuestion