Evidence map›Paper›PMID 40864712›Full record

ArticleScience advances2025

Cells prioritize the regulation of cell mass density.

Jinyu Fu, Qin Ni, Yufei Wu, Anoushka Gupta, Zhuoxu Ge, Hongru Yang, Yasin Afrida, Ishan Barman, Sean X Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Cell-nanoplastics association impacts cell proliferation and motility.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jinyu FuDepartment of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0009-3403-2565
Qin NiDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0738-1817
Yufei WuDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-7724-4359
Anoushka GuptaDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0002-5409-1561
Zhuoxu GeDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Hongru YangDepartment of Material Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yasin AfridaDepartment of Chemistry, Johns Hopkins University, Baltimore, MD, USA.
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0800-0825
Sean X SunDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9077-7088

Funding

The Role of Hydraulic Pressure in the Osmotic Engine Model of Cell MigrationR01GM134542 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SEAN X SUN · 2019 to 2026
$2.1M
NIGMS NIH HHS R01 GM134542
6 · The paper itself

Abstract

A cell's global physical state is characterized by its volume and dry mass. The ratio of cell mass to volume defines the cell mass density (CMD), which is also a measure of macromolecular crowding and concentrations of all proteins. Using the fluorescence eXclusion method (FXm) and quantitative phase microscopy (QPM), we investigate CMD dynamics following sudden changes in media osmolarity. We find that while cell volume and mass exhibit complex behavior after osmotic shock, CMD follows a straightforward monotonic recovery over 48 hours. This recovery is cell cycle independent and depends on coordinated adjustment of protein synthesis and volume growth rates. Unexpectedly, the protein synthesis rate decreases when CMD increases. We observe that nucleoplasm-cytoplasm transport is CMD dependent, which contributes to negative regulatory feedback on CMD. The Na

Indexed as

Cell SizeCell CountOsmotic PressureProtein Biosynthesis

Identifiers

PMID40864712
PMCPMC13155540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.