Evidence map›Paper›PMID 40864709›Full record

ArticleScience advances2025

Engineering noncovalent π-stacked organic framework for intrinsic near-infrared photoactivated drug delivery.

Ruxing Fu, Dong Meng, Xiao Han, Lu Liu, Chichia Chen, Ran Zheng, Yepin Zhao, Xuexiang Zhang, Xiao Lin, Mahdi Hasani and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ruxing FuDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-5755-0554
Dong MengState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering and Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-6776-0707
Xiao HanDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0009-0001-3214-8355
Lu LiuDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Chichia ChenDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0009-0005-5582-3316
Ran ZhengDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.
Yepin ZhaoDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-9988-0949
Xuexiang ZhangDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-2747-3660
Xiao LinDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Mahdi HasaniDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-2402-2573
Yang SongDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-8026-9293
Tingxizi LiangDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Di WenDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Hongjun LiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-1765-8445
Ilhan YavuzDepartment of Physics, Marmara University, Istanbul 34722, Türkiye.ORCID 0000-0002-3268-6268
Huiheng FengKey Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-2947-4456
Zhenxing LiDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-4020-7490
Song LiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-4760-8828
Feng LiuKey Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-8333-0221
Yang YangDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-8833-7641

Funding

Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA234343
6 · The paper itself

Abstract

Photoactivated drug delivery is a promising therapeutic strategy that enables spatial and temporal control of payload release. A critical component of this approach is the photoresponsive material that has sufficient drug-loading capacity and can be actuated by near-infrared (NIR) light with considerable penetration depths. Here, we establish a photoactivated drug delivery platform based on the π-stacked organic framework (πOF), which demonstrates an intrinsic NIR absorption and superior photothermal effect. πOF not only has considerable loading capacity for a variety of drugs but also prompts the inducible burst release of loaded cargoes under NIR irradiation with notable increase of the release rate. Based on these features, πOF is used to effectively modulate the delivery of resiquimod (R848) and simultaneously induce photothermal effect by NIR irradiation. In 4T1-bearing mouse models, the photoactivated release of R848 can significantly potentiate treatment efficacy.

Indexed as

Drug Delivery SystemsInfrared RaysAnimalsCell Line, TumorDrug LiberationFemaleHumansImidazolesMiceImidazoles

Identifiers

PMID40864709
PMCPMC12383264

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.