ArticleScience advances2025
Smarter biopsy decisions in thyroid nodules via dual-modal photoacoustic and ultrasound imaging.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- In-silico investigation into optimal photoacoustic probe design using a digital thyroid phantom.Journal of biomedical optics · 2027Article
- Improved quantification of photoacoustic biomarkers through residual-based noise masking.Photoacoustics · 2026Article
- Label-free ultraviolet photoacoustic microscopy for multiscale structural phenotyping of epithelial morphogenesis in organoid-derived intestinal epithelial wrinkle tissue.Photoacoustics · 2026Article
- Robust hybrid feature-driven on-the-fly mapping enables freehand 3D panoramic photoacoustic angiography.Light, science & applications · 2026Article
- Three-dimensional aperture-driven photoacoustic tomography (3D-ADPAT).Science advances · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Activatable smart contrast agents for photoacoustic imaging.Smart molecules : open access · 2026Review
- Longitudinal three-dimensional photoacoustic imaging reveals hyperoxic perilesional microvasculature associated with keloid recurrence.Photoacoustics · 2026Article
- Fabrication of optically transparent ultrasound transducers to integrate light and sound in multimodal biomedical systems.Nature protocols · 2026Review
- Fully integrated photoacoustic microscopy for multi-scale and longitudinal imaging in translational biomedical applications.Biomedical optics express · 2026Article
- HER2 Score-Aware Virtual Immunohistochemistry via Non-Contrastive Multi-Task Translation.Diagnostics (Basel, Switzerland) · 2026Article
- Volumetric photoacoustic/ultrasound image fusion and enhancement with dual-tree complex wavelet transform.Biomedical optics express · 2026Article
- From light to sound: Seeing and hearing the placenta in health and disease.Science advances · 2026Review
- A Hybrid Diffusion Model Enhances Multiparametric 3D Photoacoustic Computed Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual-database Bibliometric Analysis Combined with Gephi-based Network Visualization of Artificial Intelligence Applications in the Identification and Diagnosis of Thyroid Space-occupying Lesions.Current medical imaging · 2026Article
- Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Recent advances in photoacoustic-ultrasound dual-modality fusion imaging for functional visualization of the superficial tumor microenvironment.Oncology reviews · 2026Review
- A handheld photoacoustic microscopic probe integrating a transparent ultrasound transducer and a fiber scanner.Nature communications · 2025Article
- A three-dimensional photoacoustic and ultrasound automated breast volume scanner (PAUS-ABVS) for breast cancer patients.Science advances · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid nodules are primarily diagnosed using ultrasound imaging (USI), but its low specificity leads to unnecessary fine-needle aspiration biopsies (FNABs). In particular, USI's limited ability to differentiate follicular neoplasms from benign nodules contributes to suboptimal biopsy decision-making. We propose a dual-modal imaging approach that combines multiparametric photoacoustic imaging (PAI) and USI to support smarter biopsy decisions. In 106 patients with 29 benign nodules, 45 papillary thyroid carcinomas, and 32 follicular neoplasms, three PAI-derived parameters-the photoacoustic spectral gradient, oxygen saturation, and skewness of the oxygen saturation distribution-were combined using a support vector machine. Following USI-based American Thyroid Association (ATA) guidelines, they were used to develop the ATA-Photoacoustic (ATAP) scoring system. The ATAP score achieved 97% sensitivity and 38% specificity in distinguishing nodules requiring FNAB. Our approach enabled better identification of benign nodules, reducing unnecessary FNAB in 11 of the 29 benign cases. This dual-modal strategy can assess thyroid nodules, effectively reducing unnecessary biopsies while maintaining high diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.