Evidence map›Paper›PMID 40864686›Full record

ArticleScience translational medicine2025

NF1-depleted ER

Ze-Yi Zheng, Anran Chen, Eric J Jaehnig, Meenakshi Anurag, Jonathan T Lei, Long Feng, Chenwei Wang, Diana Fandino, Purba Singh, Hilda Kennedy and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. CDK4/6 Inhibitors in Breast Cancer-Who Should Receive Them?International journal of molecular sciences · 2025
    Review
  6. Rat somatic genome editing enables ER+ breast cancer modeling.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Ze-Yi ZhengLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-6536-4874
Anran ChenLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-1692-5051
Eric J JaehnigLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9618-6011
Meenakshi AnuragLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4379-5192
Jonathan T LeiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0209-8051
Long FengLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8612-7923
Chenwei WangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0920-8639
Diana FandinoLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Purba SinghLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Hilda KennedyLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0004-0660-2675
Ghazal YadavLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Craig T VollertLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3769-0805
Jill TsaiGuardant Health, Palo Alto, CA 94304, USA.ORCID 0000-0001-7244-4477
Xi ChenDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7995-6202
Yi LiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9976-518X
Bora LimLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-4182-6058
Alastair ThompsonDepartment of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Shunqiang LiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Charles E FouldsLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4908-1473
Bing ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8676-2425
Matthew J EllisLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8467-8534
Eric C ChangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1375-5088

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Translational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW J ELLIS · 2014 to 2026
$24.5M
THE RNA HELICASE EIF4A IS A THERAPEUTIC VULNERABILITY IN TRIPLE-NEGATIVE BREAST CANCERU54CA233223 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MITSIADES, NICHOLAS · 2018 to 2022
$7.0M
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186784NCI NIH HHS U54 CA233223
6 · The paper itself

Abstract

Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase-activating protein and estrogen receptor (ER) transcriptional corepressor. NF1

Indexed as

Breast NeoplasmsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Neurofibromin 1Protein Kinase InhibitorsReceptors, EstrogenAnimalsCell Line, TumorCell ProliferationCyclin D1FemaleHumansMicePiperazinesPyridinesXenograft Model Antitumor AssaysCDK4 protein, humanCDK6 protein, humanCyclin D1Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Neurofibromin 1NF1 protein, humanpalbociclibPiperazinesProtein Kinase InhibitorsPyridinesReceptors, Estrogen

Identifiers

PMID40864686
PMCPMC12697068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.