Evidence map›Paper›PMID 40864606›Full record

ArticleOrganic letters2025

Kinetically Controlled aza-Michael/Epimerization Cascade Enables a Scalable Total Synthesis of Putative (

Adrian O Dukes, Pathum M Weerawarna, Richard B Silverman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adrian O DukesDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
Pathum M WeerawarnaDivision of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-9859-0787
Richard B SilvermanDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-9034-1084

Funding

Ornithine Aminotransferase Inactivation, a New Approach for Treatment of CancersR01CA260250 · NCI · NORTHWESTERN UNIVERSITY · PI RICHARD B SILVERMAN · 2021 to 2026
$2.3M
NCI NIH HHS R01 CA260250
6 · The paper itself

Abstract

The first total syntheses of putative (+)-fumigaclavine F (seven pots, 16% overall yield, 400 mg scale) and its proposed biosynthetic precursor (seven pots, 21% overall yield, 400 mg scale) have been achieved. The stereochemistry of both was unambiguously verified via XRD. The synthesis features a decagram-scale asymmetric intramolecular Mannich reaction, followed by an aza-Michael/epimerization cascade that constructs the cis-fused tetracyclic scaffold. The synthesis provides an excellent approach to probe the bioactivity of clavine alkaloids.

Indexed as

AlkaloidsKineticsMolecular StructureStereoisomerismAlkaloids

Identifiers

PMID40864606
PMCPMC12459949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.