ArticleProbiotics and antimicrobial proteins2026
Effects of Three Microbiome-Based Therapies on Loperamide-Induced Constipation in Mice by Restoring Intestinal Motility and Modulating the Intestinal Microbiota.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric and visual analysis of gut microbiota research in functional bowel disorders from 2016 to 2025.Frontiers in medicine · 2026Pooled it
- Microbiota-immune crosstalk in the regulation of intestinal motility in constipation.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Constipation is a common gastrointestinal disorder, often associated with dysbiosis of the intestinal microecology. The treatments for constipation are various, and microbiome-based therapies provide supplementary or alternative options for its management. This study compared the therapeutic effects of three microbiome-based therapies, including probiotics, prebiotics, and traditional Chinese medicine (TCM), with the agonist mosapride on loperamide-induced constipation in mice, focusing on their restorative effects on intestinal motility and intestinal microecology. The results showed that mosapride had the most significant improvement in gut motility and key motility hormones, and also significantly restored gut microbiota. Probiotics significantly improved the levels of the motility hormones motilin (MTL) and substance P (SP) and significantly altered the composition of the microbiota. TCM significantly increased gut motility and was most effective in improving gut microbiota composition and short-chain fatty acid (SCFA) content. Inulin, on the other hand, had the least effect on defecation phenotype, intestinal motility, and restoration of intestinal microecology. Overall, this preclinical study in mice provides experimental insights into the therapeutic efficacy and potential mechanisms of these methods, which may contribute to the appropriate selection of candidate therapies for human constipation subtypes characterized by motility-microbiota axis dysfunction. In addition, the research highlights the critical importance of gut microbiota and their metabolites in the treatment of constipation and their potential as therapeutic indicators.
Indexed as
Identifiers
40864418What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.