ArticleCell biochemistry and biophysics2025
Identification and Analysis of the Protective Role of Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells in Sepsis-induced Intestinal Injury by Bioinformatics and Experimental Verification.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Application of Human Umbilical Cord Mesenchymal Stem Cells and Their Derived Exosomes in Gastrointestinal Diseases.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Sepsis is a systemic inflammatory response that often leads to multiple-organ dysfunction, particularly intestinal injury, which worsens prognosis. This study aims to explore the effects of exosomes derived from mesenchymal stem cells (MSCs) on intestinal injury in sepsis and their underlying mechanisms. Bioinformatics analyses of sequencing data from mouse models of spesis and lipopolysaccharide-treated intestinal epithelial cells were conducted to identify candidate genes and pathways involved in intestinal damage. Human umbilical cord MSCs were isolated, and their exosomes were administered to mouse models of spesis. Various assays were conducted to evaluate the protective role of MSC-derived exosomes. The bioinformatics analyses revealed upregulation of miR-218-5p and downregulation of Chromobox homolog 8 (Cbx8) in mouse models of spesis. Experimental results showed that exosome treatment significantly reduced intestinal inflammation, necrosis, cytokine levels (e.g., IL-1β, IL-6), and apoptosis-related proteins (e.g., caspase-3, Bax). Exosomes also restored the miR-218-5p-Cbx8 axis, confirming the bioinformatics findings. Overall, this study highlights that MSCs-derived exosomes offer a promising therapeutic strategy for sepsis-induced intestinal injury by reducing inflammation and apoptosis while modulating the miR-218-5p-Cbx8 axis, demonstrating their potential application in sepsis and other inflammatory diseases.
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Registered trials
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