ArticleJapanese journal of radiology2025
Exploring cerebral small vessel disease, choroid plexus, demographics and vascular risk factors that affect glymphatic function.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Diffusion tensor image analysis along the perivascular space (DTI-ALPS): redefining its interpretation and role.Japanese journal of radiology · 2026Review
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis.Frontiers in aging neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundCerebral small vessel disease (CSVD) is a major contributor to cognitive decline and dementia. The glymphatic system, a recently discovered brain waste clearance system, plays a critical role in maintaining brain health. This study investigates glymphatic dysfunction in CSVD using diffusion tensor imaging along perivascular spaces (DTI-ALPS) and enlarged perivascular spaces (EPVS), to identify key risk factors and modifiable influences.
methods373 participants were recruited and underwent magnetic resonance imaging. Multivariable regression and restricted cubic splines (RCS) were performed to investigate the associations between demographics, vascular risk factors, choroid plexus volume (CPV), imaging markers of CSVD, and time of day (TOD) with the glymphatic system estimated by DTI-ALPS and PVS.
resultsL-ALPS correlated with age (β = - 0.233, p < 0.001), CPV (β = - 0.100, p = 0.047), and sex (β = 0.103, p = 0.027). R-ALPS correlated with age (β = - 0.108, p = 0.040), Fazekas score (β = - 0.151, p = 0.006), male sex (β = 0.209, p < 0.001), and cerebral microbleeds (β = - 0.146, p = 0.004). The risk factors for severe BG-PVS were age (OR: 1.090, P < 0.001) and Fazekas score (OR: 2.243, P < 0.001). L-ALPS correlated with TOD (β = - 0.091, p = 0.039), particularly in females (β = - 0.147, p = 0.016).
conclusionAge, sex (male), white matter hyperintensity, CPV enlargement, and cerebral microbleeds are risk factors for glymphatic dysfunction. Circadian rhythms may modulate glymphatic activity.
Indexed as
Identifiers
40864350What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.