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ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Assessing endocrinology referral rates and osteoporosis directed-care after upper extremity fragility fractures.

Annika N Hiredesai, Alejandro M Holle, Camryn S Payne, Nathan C Beckett, Carina P Howlett, Cara H Lai, Joshua S Bingham

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

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1citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Annika N HiredesaiMayo Clinic Alix School of Medicine, 5951 East Mayo Boulevard, Phoenix, AZ, 85054, USA. hiredesai.annika@mayo.edu.ORCID http://orcid.org/0009-0009-0043-1189
Alejandro M HolleMayo Clinic Alix School of Medicine, 5951 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Camryn S PayneMayo Clinic Alix School of Medicine, 5951 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Nathan C BeckettMayo Clinic Alix School of Medicine, 5951 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Carina P HowlettMayo Clinic Alix School of Medicine, 5951 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Cara H LaiDepartment of Orthopedic Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Joshua S BinghamDepartment of Orthopedic Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upper extremity fragility fractures (UEFFs) often fail to prompt osteoporosis evaluation. In 99 UEFF patients, only 25% received endocrinology referrals, 51% underwent DXA scans (median 301 days post-fracture), and 20% initiated treatment, with males less likely to receive scans (18% vs 55%, p = 0.028). Standardized referral protocols and improved awareness are needed to address care gaps, particularly for males. PURPOSE: Upper extremity fragility fractures (UEFFs) are frequently overlooked as osteoporosis indicators, leading to missed care opportunities. This study aimed to (1) assess the endocrinology referral rate following UEFFs, (2) evaluate rates of osteoporosis-directed care initiation, and (3) identify risk factors for lack of osteoporosis-directed follow-up after UEFF.

methodsPatients with distal radius or proximal humerus fractures (2013-2023) at a United States level III trauma center were analyzed. Exclusions included high-energy trauma, prior osteoporosis therapy, age < 50, malignancy/Paget's disease, or < 1-year follow-up. Data included demographics, endocrinology referrals, DXA scans, pharmacotherapy initiation, and subsequent fractures. Risk factors were analyzed using Fisher's exact/chi-square tests.

resultsA total of 99 patients met inclusion criteria with 85 (86%) patients sustaining a distal radius fracture and 14 (14%) sustaining a proximal humerus fracture. Of these, 25% were referred to endocrinology, 21% were seen by endocrinology, and 51% received a DXA scan after the index fracture. Only 20% were initiated on pharmacotherapy. The median time to DXA was 301 days (Interquartile range: 124-552 days), with only 17 (34%) patients receiving a scan within 6 months. Males were less likely to receive a DXA scan than females (18% vs 55%, p = 0.028).

conclusionMost UEFF patients lacked timely osteoporosis evaluation, with males disproportionately affected. Standardizing referral protocols and improving osteoporosis awareness post-fracture may enhance early intervention and outcomes.

Indexed as

OsteoporosisOsteoporotic FracturesReferral and ConsultationAbsorptiometry, PhotonAgedAged, 80 and overBone Density Conservation AgentsEndocrinologyFemaleHumansMaleMiddle AgedRadius FracturesRetrospective StudiesRisk FactorsSex FactorsBone Density Conservation AgentsDXA scanEndocrinologyFragility fractureOsteoporosisReferral ratesUpper extremity

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.