Evidence map›Paper›PMID 40864225›Full record

ArticleACS chemical neuroscience2025

Donepezil and Memantine Derivatives for Dual-Function and Prodrug Applications in Alzheimer's Disease.

Karna Terpstra, Citlali Gutiérrez, Kai Gui, Liviu M Mirica

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Evaluation of a New Methylimidazole-Containing Thiosemicarbazone as a CuChemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karna TerpstraDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, Illinois 61801, United States.
Citlali GutiérrezDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, Illinois 61801, United States.
Kai GuiDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, Illinois 61801, United States.
Liviu M MiricaDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, Illinois 61801, United States.ORCID 0000-0003-0584-9508

Funding

Blood-Brain Barrier Permeable Multimodal Imaging Agents for Neurodegenerative DiseasesRF1AG083937 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MIRICA, LIVIU M. · 2023 to 2023
$1.8M
NIA NIH HHS RF1 AG083937
6 · The paper itself

Abstract

The treatment of Alzheimer's disease by acetylcholinesterase (AChE) and

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsDonepezilMemantineProdrugsAmyloid beta-PeptidesAnimalsBrainHumansMiceMice, TransgenicMolecular Docking SimulationPlaque, AmyloidReceptors, N-Methyl-D-AspartateAmyloid beta-PeptidesCholinesterase InhibitorsDonepezilMemantineProdrugsReceptors, N-Methyl-D-AspartateAlzheimer’s diseasedonepezilmemantinemetabolismmultifunctionalmultitarget directed

Identifiers

PMID40864225
PMCPMC12414536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.