Evidence map›Paper›PMID 40864224›Full record

ArticleEuropean journal of pediatrics2025

Update on pediatric inflammatory bowel diseases epidemiology during SARS-CoV-2 outbreak:data from the Italian society of pediatric gastroenterology, epatology and nutrition registry.

Patrizia Alvisi, Marco Congiu, Luca Scarallo, Marina Aloi, Claudio Romano, Dario Dilillo, Daniela Knafelz, Giovanna Zuin, Matteo Bramuzzo, Lorenzo Norsa and 9 more

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Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Patrizia AlvisiPediatric Gastroenterology Unit, Maggiore CA Pizzardi Hospital, Bologna, Italy. patrizia.alvisi@ausl.bologna.it.
Marco CongiuResidency School of Pediatrics, University of Bologna, Bologna, Italy.
Luca ScaralloGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Marina AloiPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Claudio RomanoPediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Dario DililloDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Daniela KnafelzPediatric Gastroenterology and Nutrition Unit, Bambino GesùChildren Hospital IRCCS, Rome, Italy.
Giovanna ZuinDepartment of Pediatrics, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
Matteo BramuzzoInstitute for Maternal and Child Health, IRCCS "BurloGarofolo", Trieste, Italy.
Lorenzo NorsaDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Mara CananziPediatric Gastroenterology, Digestive Endoscopy, Hepatology and Care of the Child With Liver Transplantation, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy.
Maria PastorePediatric Unit, Casa Sollievo Della Sofferenza, S. Giovanni Rotondo, Italy.
Enrico FeliciPediatric and Pediatric Emergency Unit, Children Hospital AOU SS Antonio E Biagio E C. Arrigo, Alessandria, Italy.
Serena ArrigoPediatric Gastroenterology and Endoscopy Unit, IRCSS Giannina Gaslini, Genoa, Italy.
Giulia D'ArcangeloPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Giovanna Lo PrestiPediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Micol BacchiniResidency School of Pediatrics, University of Ferrara, Ferrara, Italy.
Veronica CiprianiResidency School of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy.
Paolo LionettiGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 pandemic significantly affected clinical practice worldwide. In Italy, hospital access was limited to urgent cases in 2020. The primary aim was to assess the impact of SARS-CoV-2 on pIBD in Italy during 2020 compared to 2019 and to 2021. The secondary aim was to compare characteristics of pIBD during 2019-2021 with data from previous reports. All new pIBD diagnoses from January 1st, 2019, to December 31st, 2021, were collected through the IBD registry of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and compared with data from previous studies. A total of nine-hundred-seventy-six new pIBD diagnoses were registered over a three-year period. The lowest number was recorded in 2020 (n = 267), significantly fewer than in 2019 and 2021 (p = 0.003). The mean incidence was 3.43/100000/year compared to 1.98 in 2009-2018 (p < 0.0001). The median diagnostic delay further decreased compared to previous years despite the COVID-19 outbreak, setting at 3.6 months. The overall median age at diagnosis was significantly higher than in 2009-2018 (12.8 vs 11.7 years, p < 0.001). The use of anti-TNF-alpha agents as induction therapy significantly increased during 2019-2021 (15.3%) compared to previous reports (6.6%).

conclusionsIn 2020 the lowest pIBD incidence was observed, likely due to impact of the COVID-19 outbreak. A subsequent rise in incidence in 2021 and a reduction in diagnostic delay were noted, possibly due to the easing of restrictions. Compared to previous Italian studies, the period 2019-2021 showed an overall increase in pIBD incidence and a decrease in diagnostic delay. WHAT IS KNOWN: • Pediatric Inflammatory Bowel Diseases (pIBD) incidence is increasing worldwide, primarily in industrialized countries. • During SARS-CoV-2 pandemic, patients tended to postpone the use of medical cares and hospital accesses were limited to emergencies. WHAT IS NEW: • In Italy, during years 2019-2021, pIBD incidence increased and pIBD diagnostic delay shortened compared to the past, despite COVID-19 outbreak. • Prevalence of pIBD in adolescents during 2019-2021 turned out to be higher compared to previous reports. • Despite restrictions, the use of anti-TNF-alpha agents significantly increased compared to previous Italian reports.

Indexed as

COVID-19Inflammatory Bowel DiseasesAdolescentChildChild, PreschoolDelayed DiagnosisFemaleHumansIncidenceInfantItalyMalePandemicsRegistriesSARS-CoV-2Societies, MedicalCOVID-19 pandemicDiagnostic delayEpidemiologyMinimum incidencePediatric IBD

Identifiers

PMID40864224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.