Observational studyArchives of osteoporosis2025
Trends in the prevalence of hypovitaminosis D over a 10-year period in Japan: the research on osteoarthritis/osteoporosis against disability study 2005-2015.
Observational study in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Sex-Based Differences in the Vitamin D Metabolite Ratio and Its Associated Factors Among Healthy Japanese Adults: A Cross-Sectional Study.Biomedicines · 2026Article
- Vitamin D status and site-specific fracture pattern associations in older adults with fragility fractures: a cross-sectional analysis of 2543 patients.Frontiers in nutrition · 2026Article
- Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton.Frontiers in endocrinology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
We examined the trends in vitamin D insufficiency and deficiency over a 10-year period in the general population. The prevalence of deficiency significantly decreased (29.5% vs. 21.6%), whereas mean serum levels increased (23.3 ng/mL vs. 25.1 ng/mL). These trends may reduce the incidence of osteoporosis and osteoporotic fractures. PURPOSE: We aimed to clarify the trends in the prevalence of vitamin D insufficiency and deficiency in the general population using population-based cohort data from a baseline survey and a follow-up survey conducted 10 years later.
methodsA baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted from 2005 to 2007. Blood samples were collected to measure serum 25-hydroxyvitamin D (25D) and intact parathyroid hormone levels from 1,683 participants (595 men, 1,088 women). Participants also completed an interviewer-administered questionnaire, and underwent bone mineral density measurements and radiographic examinations. The fourth survey was conducted from 2015 to 2016 with 1,906 individuals (637 men, 1,269 women), including both follow-up participants from the baseline survey and newly recruited individuals to increase the sample size for future longitudinal analyses. All participants completed assessments identical to those in the baseline survey. Vitamin D deficiency and insufficiency were defined as serum 25D levels of < 20 ng/mL and ≥ 20 ng/mL but < 30 ng/mL, respectively.
resultsThe mean serum vitamin D levels were 23.3 ng/mL at baseline and 25.1 ng/mL at the fourth survey, indicating a significant increase (p < 0.001). The prevalences of vitamin D insufficiency and deficiency were 52.9% and 29.5%, respectively, at baseline, and 54.8% and 21.6%, respectively, in the fourth survey, indicating a significant decrease in vitamin D deficiency (p < 0.001).
conclusionsIn this population-based survey with a 10-year interval, the prevalence of hypovitaminosis D significantly decreased. This favourable trend may contribute to future reductions in the incidence of osteoporosis and osteoporotic fractures.
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