Evidence map›Paper›PMID 40864098›Full record

ArticleToxins2025

A Lyophilizable Nanoparticle Vaccine Specific for a Novel Linear Neutralizing Epitope in the α2-α3 Helices of Domain 3 of Lethal Factor from

Jon Oscherwitz, Kemp Cease, David Milich, Thomas Braun, Fen Yu, David Whitacre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Human anthrax vaccines: Current status and future prospects.Human vaccines & immunotherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jon OscherwitzDivision of Hematology-Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Kemp CeaseDivision of Hematology-Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
David MilichVLP Biotech, Inc., 3030 Bunker Hill St., Ste 117D, San Diego, CA 92109, USA.
Thomas BraunDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0002-7113-6998
Fen YuDivision of Hematology-Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
David WhitacreVLP Biotech, Inc., 3030 Bunker Hill St., Ste 117D, San Diego, CA 92109, USA.ORCID 0000-0003-3803-9157

Funding

An epitope-focused nanoparticle vaccine for anthraxR44AI142939 · NIAID · VLP BIOTECH, INC. · PI WHITACRE, DAVID C · 2019 to 2021
$2.3M
A molecularly targeted pre- and post-exposure vaccine for anthraxR41AI106153 · NIAID · VLP BIOTECH, INC. · PI OSCHERWITZ, JON, WHITACRE, DAVID C · 2014 to 2015
$510k
National Institute of Allergy and Infectious Diseases AI106153; AI142939NIAID NIH HHS R41 AI106153NIAID NIH HHS R44 AI142939
6 · The paper itself

Abstract

Anthrax remains a serious bioterrorism threat for which new and thermostable vaccines are needed. We previously demonstrated that immunization of rabbits with multiple-antigenic-peptide (MAP) vaccines elicit antibody (Ab) against the loop-neutralizing-determinant (LND), a cryptic linear neutralizing epitope in the 2β2-2β3 loop of protective antigen (PA) from

Indexed as

AnthraxAnthrax VaccinesAntigens, BacterialBacillus anthracisBacterial ToxinsEpitopesNanoparticlesVaccines, Virus-Like ParticleAnimalsAntibodies, BacterialAntibodies, NeutralizingFreeze DryingNanovaccinesRabbitsanthrax toxinAnthrax VaccinesAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialBacterial ToxinsEpitopesNanovaccinesVaccines, Virus-Like ParticleanthraxantibodyBacillus anthracislethal factorlyophilizationneutralizationvaccinevirus-like particle

Identifiers

PMID40864098
PMCPMC12389915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.