Evidence map›Paper›PMID 40864087›Full record

ArticleToxins2025

Pioneering Comparative Proteomic and Enzymatic Profiling of Amazonian Scorpion Venoms Enables the Isolation of Their First α-Ktx, Metalloprotease, and Phospholipase A

Karla C F Bordon, Gabrielle C Santos, Jonas G Martins, Gisele A Wiezel, Fernanda G Amorim, Thomas Crasset, Damien Redureau, Loïc Quinton, Rudi E L Procópio, Eliane C Arantes

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Proteomic characterization ofThe journal of venomous animals and toxins including tropical diseases · 2026
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karla C F BordonDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0001-6540-2295
Gabrielle C SantosDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto 14040-903, SP, Brazil.
Jonas G MartinsGraduate Program in Genetics, Conservation and Evolutionary Biology (PPG GCBEv), National Institute for Amazon Research (INPA), Manaus 69067-375, AM, Brazil.
Gisele A WiezelDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0001-9791-0630
Fernanda G AmorimLaboratory of Mass Spectrometry, MolSys Research Unit, University of Liège, B-4000 Liège, Belgium.ORCID 0000-0003-1453-3185
Thomas CrassetLaboratory of Mass Spectrometry, MolSys Research Unit, University of Liège, B-4000 Liège, Belgium.ORCID 0009-0006-3272-8233
Damien RedureauLaboratory of Mass Spectrometry, MolSys Research Unit, University of Liège, B-4000 Liège, Belgium.
Loïc QuintonLaboratory of Mass Spectrometry, MolSys Research Unit, University of Liège, B-4000 Liège, Belgium.ORCID 0000-0001-8153-9590
Rudi E L ProcópioGraduate Program in Biotechnology and Natural Resources of Amazon, University of the State of Amazonas (UEA), Manaus 69050-020, AM, Brazil.ORCID 0000-0002-8538-4642
Eliane C ArantesDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-6712-6033

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/27544-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11936-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/01083-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10051-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10128-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10953-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/16842-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2025/01816-1Fundação de Amparo à Pesquisa do Estado do Amazonas POSGRAD 353/2023National Council for Scientific and Technological Development 309399/2021-1
6 · The paper itself

Abstract

Scorpionism is a growing public health concern in Brazil, with the Amazon region presenting the highest mortality rates but remaining understudied, especially regarding local scorpion venoms composition. This study presents the first comprehensive biochemical characterization of venoms from three Amazonian species-

Indexed as

MetalloproteasesPhospholipases A2Scorpion VenomsAnimalsBrazilProteomicsScorpionsMetalloproteasesPhospholipases A2Scorpion VenomsAmazon rainforestButhidaeChactidaeenzymegeographic variationmass spectrometrymetallopeptidaseneuroactive peptidestoxinologyvenomics

Identifiers

PMID40864087
PMCPMC12390242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.