Evidence map›Paper›PMID 40864085›Full record

ArticleToxins2025

Effect of Dietary Difructose Anhydride III Supplementation on the Metabolic Profile of Japanese Black Breeding Herds with Low-Level Chronic Exposure to Zearalenone in the Dietary Feed.

Topas Wicaksono Priyo, Naoya Sasazaki, Katsuki Toda, Hiroshi Hasunuma, Daisaku Matsumoto, Emiko Kokushi, Seiichi Uno, Osamu Yamato, Takeshi Obi, Urara Shinya and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Topas Wicaksono PriyoJoint Graduate School of Veterinary Sciences, Yamaguchi University, Yamaguchi 753-8515, Japan.ORCID 0000-0002-6213-8844
Naoya SasazakiShepherd Central Livestock Clinic, Kagoshima 899-1611, Japan.
Katsuki TodaShepherd Central Livestock Clinic, Kagoshima 899-1611, Japan.
Hiroshi HasunumaShepherd Central Livestock Clinic, Kagoshima 899-1611, Japan.
Daisaku MatsumotoShepherd Central Livestock Clinic, Kagoshima 899-1611, Japan.
Emiko KokushiFaculty of Fisheries, Kagoshima University, Kagoshima 890-0056, Japan.
Seiichi UnoFaculty of Fisheries, Kagoshima University, Kagoshima 890-0056, Japan.ORCID 0000-0003-0897-7804
Osamu YamatoJoint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0062, Japan.ORCID 0000-0002-4430-5645
Takeshi ObiJoint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0062, Japan.
Urara ShinyaSoo Veterinary Clinic, Kagoshima A.M.A.A., Soo 899-8242, Japan.
Oky Setyo WidodoDivision of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0002-0073-1394
Yasuho TauraJoint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan.
Tetsushi OnoJoint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan.
Masayasu TaniguchiJoint Graduate School of Veterinary Sciences, Yamaguchi University, Yamaguchi 753-8515, Japan.ORCID 0000-0003-3422-1904
Mitsuhiro TakagiJoint Graduate School of Veterinary Sciences, Yamaguchi University, Yamaguchi 753-8515, Japan.

Funding

Nippon Beet Sugar Manufacturing Co., Ltd, Obihiro Japan Not available
6 · The paper itself

Abstract

Mycotoxin contamination in animal feed can cause acute or chronic adverse effects on growth, productivity, and immune function in livestock. This study aimed to evaluate the impact of difructose anhydride III (DFA III) supplementation on serum biochemical parameters and intestinal environment in Japanese Black (JB) breeding cows under low-level chronic dietary exposure to zearalenone (ZEN). Using urinary ZEN concentration as an indicator of exposure, 25 JB cows were selected from a breeding farm with confirmed natural feed contamination. Blood samples were collected before DFA III supplementation (day 0), and on days 20 and 40 post-supplementation. Serum biochemical parameters and short-chain fatty acid concentrations were measured. During the studies, dietary ZEN concentration increased, yet improvements were observed in liver function, nutritional status, immune response, and inflammatory markers. Notably, serum butyrate concentration significantly increased following DFA III administration. These findings suggest that DFA III may positively influence intestinal microflora and enhance intestinal barrier function, which could contribute to improved health and nutritional status in cattle exposed to low-level chronic dietary ZEN contamination. DFA III supplementation may represent a promising strategy for mitigating the effects of low-level mycotoxin exposure in livestock production systems.

Indexed as

Animal FeedDietary SupplementsFood ContaminationZearalenoneAnimalsCattleDietDietary ExposureDisaccharidesFatty Acids, VolatileFemaleGastrointestinal MicrobiomeMetabolomedifructose anhydride IIIDisaccharidesFatty Acids, VolatileZearalenonedifructose anhydride IIIintestinal barrier functionJapanese Black cattlemetabolic profilezearalenone

Identifiers

PMID40864085
PMCPMC12390375

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.