Evidence map›Paper›PMID 40864035›Full record

ArticleJACC. Asia2026

The Effect of Volume-Flow Discordance on Survival in Severe Aortic Stenosis.

Sara L Hungerford, Ning Song, Brandon Loo, Eleanor Rye, Hari Sritharan, Kay D Everett, Christopher S Hayward, Navin K Kapur, David W M Muller, Audrey I Adji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara L HungerfordThe CardioVascular Center Tufts, Boston, Massachusetts, USA; Faculty of Medicine and Health, University of Sydney, Sydney Australia; Department of Cardiology, Royal North Shore Hospital, Sydney, Australia. Electronic address: sara.hungerford@sydney.edu.au.
Ning SongFaculty of Health and Medicine the University of New South Wales, Sydney, Australia; Department of Cardiology, St Vincent's Hospital, Sydney, Australia; Victor Chang Cardiac Research Institute, Sydney, Australia.
Brandon LooDepartment of Cardiology, Royal North Shore Hospital, Sydney, Australia.
Eleanor RyeDepartment of Cardiology, Royal North Shore Hospital, Sydney, Australia.
Hari SritharanDepartment of Cardiology, Royal North Shore Hospital, Sydney, Australia.
Kay D EverettThe CardioVascular Center Tufts, Boston, Massachusetts, USA.
Christopher S HaywardFaculty of Health and Medicine the University of New South Wales, Sydney, Australia; Department of Cardiology, St Vincent's Hospital, Sydney, Australia; Victor Chang Cardiac Research Institute, Sydney, Australia.
Navin K KapurThe CardioVascular Center Tufts, Boston, Massachusetts, USA.
David W M MullerFaculty of Health and Medicine the University of New South Wales, Sydney, Australia; Department of Cardiology, St Vincent's Hospital, Sydney, Australia.
Audrey I AdjiFaculty of Health and Medicine the University of New South Wales, Sydney, Australia; Department of Cardiology, St Vincent's Hospital, Sydney, Australia; Victor Chang Cardiac Research Institute, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent flow (Q) assessment in aortic stenosis (AS) uses stroke volume index (SVi), a volume (V)-based measure. However, V differs fundamentally from Q, which is defined as volume per unit time (mL/s).

objectivesThis study evaluates the prognostic significance of volume-flow (V-Q) discordance in patients with severe AS (aortic valve area <1 cm

methodsWe studied 291 patients >65 years of age who underwent TAVR over 5 years (median follow-up, 3.0 years; [Q1-Q3: 3.0-3.0 years]). Aortic flow was assessed using Doppler echocardiography; transaortic flow rate (TFR) was calculated mathematically. Low V-Q discordance was defined as SVi <35 mL/m

resultsV-Q discordance was observed in 29% of patients (15% low, 14% normal). Among those with SVi <35 mL/m

conclusionsV-Q discordance occurs in nearly one-third of patients with AS post-TAVR and offers superior prognostic value over existing SVi and TFR thresholds.

Indexed as

aortic stenosisechocardiographyflow rateleft ventricular functionstroke volume indexedvolume-flow discordance

Identifiers

PMID40864035
PMCPMC12833602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.