Evidence map›Paper›PMID 40863964›Full record

ArticleToxics2025

Effects of Environmental Cadmium Exposure Sufficient to Induce Renal Tubular Dysfunction on Bone Mineral Density Among Female Farmers in Cadmium-Polluted Areas in Northern Japan.

Hyogo Horiguchi, Etsuko Oguma, Kayoko Miyamoto, Yoko Hosoi, Fujio Kayama

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyogo HoriguchiDepartment of Hygiene, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.ORCID 0000-0002-5376-8844
Etsuko OgumaDepartment of Hygiene, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
Kayoko MiyamotoDepartment of Environmental and Preventive Medicine, School of Medicine, Jichi Medical University, Shimotsuke-shi 329-0498, Japan.
Yoko HosoiDepartment of Environmental and Preventive Medicine, School of Medicine, Jichi Medical University, Shimotsuke-shi 329-0498, Japan.
Fujio KayamaDepartment of Environmental and Preventive Medicine, School of Medicine, Jichi Medical University, Shimotsuke-shi 329-0498, Japan.

Funding

the Food Safety Commission, Cabinet Office, Government of Japan JPCAFSC20242409
6 · The paper itself

Abstract

In the Japanese Multi-Centered Environmental Toxicant Study (JMETS) conducted in five areas across Japan, we demonstrated that bone mineral density (BMD) in female farmers without renal tubular dysfunction was not adversely affected by exposure to low to moderate levels of cadmium (Cd). We then expanded JMETS to the most Cd-polluted area in northern Japan, Akita prefecture, with area A as the control and areas B and C as Cd-polluted areas (Cd exposure levels: B < C), which also covered more female farmers with a wider age range (20-82 years) and Cd exposure sufficient to induce renal tubular dysfunction. We selected 1267 eligible subjects in the three areas and classified them by age and menstrual status. The distribution of blood and urinary Cd levels over the areas was A < B < C (blood Cd: 2.10, 3.78, and 3.39 µg/L, and urinary Cd: 3.02, 4.29, and 6.15 µg/g cr., respectively;

Indexed as

bonecadmiumfarmersrenal tubular dysfunction

Identifiers

PMID40863964
PMCPMC12390584

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.