Human Skin Permeation of Ethoxy- and Propoxypropanol Commonly Found in Water-Based Products.

Hélène P De Luca, Jennifer Pache, Philipp Spring, Aurélie Berthet, Nancy B Hopf

Abstract read

In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Propylene Glycol Ethers: Widespread Use and Missing Neurotoxicity Testing.Toxics · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hélène P De LucaUnisanté, University Center for Primary Care and Public Health & University of Lausanne, 1066 Lausanne, Switzerland.ORCID 0000-0001-5429-5148

Jennifer PacheUnisanté, University Center for Primary Care and Public Health & University of Lausanne, 1066 Lausanne, Switzerland.ORCID 0009-0009-1399-4191

Philipp SpringDepartment of Dermatology, Lausanne University Hospital (CHUV), 1066 Lausanne, Switzerland.

Aurélie BerthetUnisanté, University Center for Primary Care and Public Health & University of Lausanne, 1066 Lausanne, Switzerland.ORCID 0000-0002-8625-5156

Nancy B HopfDepartment of Dermatology, Lausanne University Hospital (CHUV), 1066 Lausanne, Switzerland.ORCID 0000-0002-4490-6109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some propylene glycol ethers (PGEs) have been associated with reproductive toxicity. Ethoxypropanol (PGEE) and propoxypropanol (PGPE) are two common PGEs found in many commercial products. Although skin exposure is frequent when handling such products, no studies have investigated their skin absorption. Neat or aqueous concentrations of PGEs were applied with different concentrations on previously frozen human skin according to OECD guidelines. We also explored the use of frozen skin for skin irritation screening. Our results show that both PGEs readily permeate human skin (permeation coefficients: Kp

Indexed as

biomonitoringexposomeorganic solventsrisk assessmentskin absorption

Identifiers

PMID40863951

DOI10.3390/toxics13080675

PMCPMC12390126

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.