Evidence map›Paper›PMID 40863939›Full record

ArticleToxics2025

Exposure of Domestic Cats (

Vesna Cerkvenik-Flajs, Detlef Schenke, Simona Korenjak-Černe, Anton Perpar, Jens Jacob, Susanne Schwonbeck, Sven Kleine Bardenhorst, Torsten Hahn, Marko Cvetko, Mitja Gombač

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vesna Cerkvenik-FlajsVeterinary Faculty, Institute of Pathology, Wild Animals, Fish and Bees, University of Ljubljana, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-3876-8897
Detlef SchenkeJulius Kühn Institute (JKI)-Federal Research Centre for Cultivated Plants, Institute for Ecological Chemistry, Plant Analysis and Stored Product Protection, Königin-Luise Str. 19, D-14195 Berlin, Germany.
Simona Korenjak-ČerneSchool of Economics and Business, University of Ljubljana, Kardeljeva ploščad 17, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-2715-2210
Anton PerparBiotechnical Faculty, Department of Agronomy, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana, Slovenia.ORCID 0009-0008-2961-319X
Jens JacobJulius Kühn Institute (JKI)-Federal Research Centre for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics, Rodent Research, Toppheideweg 88, D-48161 Münster, Germany.ORCID 0000-0002-5136-6606
Susanne SchwonbeckFraunhofer Institute for Toxicology and Experimental Medicine ITEM, Nikolai-Fuchs-Str. 1, D-30625 Hannover, Germany.
Sven Kleine BardenhorstInstitute of Epidemiology and Social Medicine, University of Münster, Albert-Schweitzer-Campus-1, D-48149 Münster, Germany.ORCID 0000-0002-7661-6931
Torsten HahnFraunhofer Institute for Toxicology and Experimental Medicine ITEM, Nikolai-Fuchs-Str. 1, D-30625 Hannover, Germany.
Marko CvetkoVeterinary Faculty, Institute of Pathology, Wild Animals, Fish and Bees, University of Ljubljana, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
Mitja GombačVeterinary Faculty, Institute of Pathology, Wild Animals, Fish and Bees, University of Ljubljana, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.

Funding

Ministry of Higher Education Science, and Technology P1-0294The Slovenian Research and Innovation Agency P4-0092
6 · The paper itself

Abstract

Anticoagulant rodenticides (ARs) are highly effective, but can be of environmental concern due to primary and secondary non-target exposure, with the latter possible being relevant to domestic cats. Therefore, liver residues of ARs and an alternative rodenticide, α-chloralose, were systematically monitored in domestic cats for the first time in the current study. In 2021 and 2022, the carcasses of 99 cats were collected in Slovenia and liver residues were measured by using solid supported liquid-liquid extraction and LC-MS/MS. The results show that 65% of cats carried at least one rodenticide. The second-generation ARs brodifacoum and bromadiolone were most prevalent and found in 53.5 and 25.3% of the samples, respectively. Of first-generation ARs, coumatetralyl was the most prevalent (21.2% of cats). More compounds were detected at high human population density, low farm density and in rural versus intermediate landscapes, but no effect was found for livestock density. Similar trends were found for the presence of brodifacoum, bromadiolone and all rodenticides combined. Farm density was negatively correlated with brodifacoum liver concentration. Individual factors (cat age, sex, outdoor activity) did not matter. The results indicate that a reasonably populated rural landscape, and not the rural or intermediate environment as such, is the main driver of cat exposure to ARs. The risk quotient (RQ) of worst-case acute brodifacoum poisoning was 1506. In summary, a potential environmental problem is globally highlighted for cats that is probably related to secondary exposure to ARs, with a pattern different to that seen in wild predators. Cats are an appropriate sentinel species for assessing rodenticide exposure and endangerment in the environment.

Indexed as

anticoagulant toxicantsdomestic catsenvironmental monitoringmass spectrometryrisk assessmentα-chloralose

Identifiers

PMID40863939
PMCPMC12390110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.