Evidence map›Paper›PMID 40863874›Full record

ReviewTomography (Ann Arbor, Mich.)2025

Emerging PET Imaging Agents and Targeted Radioligand Therapy: A Review of Clinical Applications and Trials.

Maierdan Palihati, Jeeban Paul Das, Randy Yeh, Kathleen Capaccione

Abstract readReview
In one paragraph

Review in Tomography (Ann Arbor, Mich.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Triple-tracer PET (Scientific reports · 2026
    Article
  3. Review
  4. Future of radiotheranostics.BMJ oncology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maierdan PalihatiDepartment of Radiology, Columbia University Irving Medical Center, 622 W 168th St., New York, NY 10032, USA.ORCID 0000-0002-1943-3901
Jeeban Paul DasDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Randy YehDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kathleen CapaccioneDepartment of Radiology, Columbia University Irving Medical Center, 622 W 168th St., New York, NY 10032, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Targeted radioligand therapy (RLT) is an emerging field in anticancer therapeutics with great potential across tumor types and stages of disease. While much progress has focused on agents targeting somatostatin receptors and prostate-specific membrane antigen (PSMA), the same advanced radioconjugation methods and molecular targeting have spurred the development of numerous theranostic combinations for other targets. A number of the most promising agents have progressed to clinical trials and are poised to change the landscape of positron emission tomography (PET) imaging. Here, we present recent data on some of the most important emerging molecular targeted agents with their exemplar clinical images, including agents targeting fibroblast activation protein (FAP), hypoxia markers, gastrin-releasing peptide receptors (GRPrs), and integrins. These radiopharmaceuticals share the promising characteristic of being able to image multiple types of cancer. Early clinical trials have already demonstrated superiority to

Indexed as

Molecular Targeted TherapyNeoplasmsPositron-Emission TomographyRadiopharmaceuticalsClinical Trials as TopicHumansReceptors, BombesinRadiopharmaceuticalsReceptors, Bombesinclinical trialsfibroblast activation protein (FAP)gastrin-releasing peptide receptors (GRPrs)hypoxiaintegrinsradiopharmaceuticals

Identifiers

PMID40863874
PMCPMC12390037

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.