Exploring the Relationship of Cognitive Disengagement Syndrome and Attention Deficit/Hyperactivity Disorder with Emotional Dysregulation: A Twin Study in Childhood and Adolescence.

Simona Scaini, Stefano De Francesco, Ludovica Giani, Marco Battaglia, Emanuela Medda, Corrado Fagnani

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Article in Methods and protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Simona ScainiChild and Youth Lab, Sigmund Freud University, 20143 Milan, Italy.ORCID 0000-0002-5978-7165

Stefano De FrancescoChild and Youth Lab, Sigmund Freud University, 20143 Milan, Italy.ORCID 0009-0004-6601-2976

Ludovica GianiChild and Youth Lab, Sigmund Freud University, 20143 Milan, Italy.

Marco BattagliaCentre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.

Emanuela MeddaCenter for Behavioural Sciences and Mental Health, Italian Twin Registry, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-4837-4549

Corrado FagnaniCenter for Behavioural Sciences and Mental Health, Italian Twin Registry, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-5771-7772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on the genetic and environmental factors underlying the co-occurrence of Cognitive Disengagement Syndrome (CDS), Attention Deficit Hyperactivity Disorder (ADHD), and Emotional Dysregulation (ED) are limited. This study aimed to explore the nature of the associations between CDS, ADHD with ED, and to assess the role of shared etiological factors in explaining their comorbidity. We analyzed a sample of 400 Italian twin pairs aged 8-18, from Northern Italy and enrolled in the Italian Twin Registry. Bivariate genetic analyses were conducted using parent-rated CBCL scores for CDS, ADHD, and ED. For both CDS-ED and ADHD-ED associations, the best-fitting models were Cholesky AE models (-2LL = -849.167 and -339.030, respectively;

Indexed as

ADHDcognitive disengagement syndromeemotion regulationsluggish cognitive tempotwin study

Identifiers

PMID40863744

DOI10.3390/mps8040094

PMCPMC12388083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.