Evidence map›Paper›PMID 40863741›Full record

ArticleMethods and protocols2025

Integrating Cartilage Explant Culture with Simulated Digestion and Hepatic Biotransformation Refines In Vitro Screening of Joint Care Nutraceuticals.

Michelina Crosbie, Kailey Vanderboom, Jamie Souccar-Young, Wendy Pearson

Abstract read
In one paragraph

Article in Methods and protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michelina CrosbieDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0009-0009-0038-0801
Kailey VanderboomDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Jamie Souccar-YoungDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Wendy PearsonDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-3635-4594

Funding

Platinum Performance 056391
6 · The paper itself

Abstract

In vitro cartilage explant culture has been used to assess nutraceuticals on cartilage responses to inflammatory stimuli. However, applying extracts of nutraceuticals directly to cartilage explants does not account for effects of digestion and hepatic biotransformation, or selective exclusion of product metabolites from joint fluid by the synovial membrane. The current study produced a simulated biological extract of a common nutraceutical (glucosamine; G

Indexed as

anti-inflammatoryarthritischondroprotectiveglucosaminenutraceuticals

Identifiers

PMID40863741
PMCPMC12388657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.