Evidence map›Paper›PMID 40863608›Full record

ArticleMembranes2025

Membrane Stress Enhances Specific PQS-Lipid Interactions That Drive Bacterial Outer Membrane Vesicle Biogenesis.

Citrupa Gopal, Hasan Al Tarify, Emad Pirhadi, Eliza G O'Brien, Anuradha Dagar, Xin Yong, Jeffrey W Schertzer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Citrupa GopalDepartment of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA.ORCID 0009-0001-3601-4063
Hasan Al TarifyDepartment of Mechanical Engineering, Binghamton University, Binghamton, NY 13902, USA.
Emad PirhadiDepartment of Mechanical Engineering, Binghamton University, Binghamton, NY 13902, USA.
Eliza G O'BrienDepartment of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA.
Anuradha DagarDepartment of Chemistry, Binghamton University, Binghamton, NY 13902, USA.
Xin YongDepartment of Mechanical Engineering, Binghamton University, Binghamton, NY 13902, USA.ORCID 0000-0002-8894-2750
Jeffrey W SchertzerDepartment of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA.ORCID 0000-0002-7658-0860

Funding

Small-molecule membrane interactions as a driver of bacterial outer membrane vesicle biogenesis across speciesR15GM135862 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI SCHERTZER, JEFFREY · 2020 to 2020
$448k
NIGMS NIH HHS R15 GM135862NIH (NIGMS) 1R15GM135862-01
6 · The paper itself

Abstract

Gram-negative bacteria use outer membrane vesicles (OMVs) for toxin trafficking, immune interference, horizontal gene transfer, antibiotic protection, and cell-cell communication. Despite their direct contribution to many pathogenesis-related behaviors, our understanding of how OMVs are produced remains surprisingly incomplete. The Bilayer Couple model describes the induction of OMV formation resulting from the preferential accumulation of small molecules in the outer leaflet of the membrane, resulting in leaflet expansion and membrane bending. Previous work has highlighted the importance of the structure of the

Indexed as

Bilayer-Couplefree energy analysismembrane stressmolecular dynamics simulationouter membrane vesiclesPseudomonas aeruginosaPseudomonas quinolone signal

Identifiers

PMID40863608
PMCPMC12388362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.