Evidence map›Paper›PMID 40863578›Full record

ArticleGeriatrics (Basel, Switzerland)2025

Adverse Childhood Experiences and Sarcopenia in Later Life: Baseline Data from the Canadian Longitudinal Study on Aging.

Menelaos M Dimitriadis, Kitty J E Kokkeler, Emiel O Hoogendijk, Radboud M Marijnissen, Ivan Aprahamian, Hans W Jeuring, Richard C Oude Voshaar

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In one paragraph

Article in Geriatrics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Menelaos M DimitriadisDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Kitty J E KokkelerDepartment of Old Age Psychiatry, ProPersona, Wolfheze 2, 6874 BE Wolfheze, The Netherlands.
Emiel O HoogendijkDepartment of Epidemiology & Data Science, Amsterdam Public Health Research Institute, Amsterdam UMC-Location VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0001-9660-5108
Radboud M MarijnissenDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-0259-7480
Ivan AprahamianGeriatrics Division & GIMMA Translational Research Group, Jundiaí Medical School, Jundiaí 13202-550, São Paulo, Brazil.ORCID 0000-0003-3806-7895
Hans W JeuringDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-0131-0735
Richard C Oude VoshaarDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-1501-4774

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsAdverse Childhood Experiences (ACEs) are linked to early and long-lasting mental health issues and somatic multimorbidity. Emerging evidence suggests ACEs may also accelerate physical frailty in old age. This study examines the association between ACEs and sarcopenia, an ageing-related disease and core component of frailty.

methodsBaseline data from the Canadian Longitudinal Study on Aging (CLSA), including 25,327 participants aged 45-85 years (50.3% female sex) were analyzed. Sarcopenia was defined using the revised European Working Group of Sarcopenia in Older People (EWGSOP2) guidelines. ACE were assessed via the Childhood Experiences of Violence Questionnaire and the National Longitudinal Study of Adolescent to Adult Health Wave III questionnaire, covering eight ACE categories. Multiple logistic regression models examined the association between the number of ACE count and sarcopenia, which were adjusted for age, sex, education, income, and ethnicity.

resultsGiven a significant interaction between age and ACE (

conclusionsHigher ACE exposure was not associated with sarcopenia in middle aged and older adults. The unexpected protective association in the oldest-old subgroup may reflect survival bias. Age-stratified longitudinal studies are needed to clarify this relationship.

Indexed as

ACEadverse childhood experiencesagedagingfrailtysarcopenia

Identifiers

PMID40863578
PMCPMC12385185

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.