Sinus Tachycardia and Unrelieved Wall Stress Precede Left Ventricular Systolic Dysfunction During Preclinical Cardiomyopathic Changes in Duchenne Muscular Dystrophy.

Takeshi Tsuda, Amy Walczak, Karen O'Neil

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In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Takeshi TsudaNemours Cardiac Center, Nemours Children's Health Delaware, 1600 Rockland Rd., Wilmington, DE 19803, USA.ORCID 0000-0001-8110-1388

Amy WalczakNemours Cardiac Center, Nemours Children's Health Delaware, 1600 Rockland Rd., Wilmington, DE 19803, USA.

Karen O'NeilNemours Cardiac Center, Nemours Children's Health Delaware, 1600 Rockland Rd., Wilmington, DE 19803, USA.

Funding

TRAJECTORIES OF CHANGE IN BMI STATUS IN EARLY CHILDHOODP20RR020173 · NCRR · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI ROSS, JUDITH L · 2004 to 2011

$14.9M

NCRR NIH HHS P20 RR020173

6 · The paper itself

Abstract

backgroundThe onset of cardiomyopathy in Duchenne muscular dystrophy (DMD) is insidious and poorly defined. We proposed integrated wall stress (iWS) as a marker of total left ventricular (LV) workload and tested whether the increased iWS represents early DMD cardiomyopathy.

methodsPeak systolic wall stress (PS-WS) was calculated in M-mode echocardiography with simultaneous blood pressure measurement. iWS was defined as a product of PS-WS and heart rate (HR) divided by 60 (=PS-WS/RR interval). We measured iWS in normal controls (CTRL), DMD with normal LV shortening fraction (%LVSF ≥ 30%) (DMD-A), and DMD with decreased %LVSF (<30%) (DMD-B).

results40 CTRL and 79 DMD patients were studied. Despite comparable %LVSF, both HR and iWS were significantly higher in DMD-A (n = 50) than in CTRL (

conclusionsiWS significantly increased in DMD before %LVSF declined. The progressive increase of iWS in DMD is initially associated with increased HR and then with increased PS-WS. iWS may serve as a useful echocardiographic marker in identifying preclinical DMD cardiomyopathy.

Indexed as

cardiomyopathydystrophinechocardiographymechanosensormuscular dystrophywall stress

Identifiers

PMID40863346

DOI10.3390/jcdd12080280

PMCPMC12387109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.