Evidence map›Paper›PMID 40863308›Full record

ArticleJournal of functional biomaterials2025

Promoting Surface Energy and Osteoblast Viability on Zirconia Implant Abutments Through Glass-Ceramic Spray Deposition Technology.

Wen-Chieh Hsu, Tao-Yu Cha, Yu-Chin Yao, Chien-Ming Kang, Sheng-Han Wu, Yuichi Mine, Chien-Fu Tseng, I-Ta Lee, Dan-Jae Lin, Tzu-Yu Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wen-Chieh HsuSchool of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Tao-Yu ChaCenter for Tooth Bank and Dental Stem Cell Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Yu-Chin YaoCenter for Tooth Bank and Dental Stem Cell Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chien-Ming KangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Sheng-Han WuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Yuichi MineDepartment of Medical Systems Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0002-7057-1955
Chien-Fu TsengCenter for Tooth Bank and Dental Stem Cell Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-8451-0280
Dan-Jae LinDepartment of Biomedical Engineering, College of Biomedical Engineering, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0001-8967-7090
Tzu-Yu PengSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-7168-9429

Funding

China Medical University CMU107-S-53Division of Research Planning and Development, Department of Research and Development, Taoyuan General Hospital, Ministry of Health and Welfare PTH114058Division of Research Planning and Development, Department of Research and Development, Taoyuan General Hospital, Ministry of Health and Welfare PTH114075National Science and Technology Council of Taiwan 112-2314-B-038-118-MY2
6 · The paper itself

Abstract

Zirconia is used widely for high-precision custom abutments; however, stress concentration can compromise osseointegration. Although glass-ceramic spray deposition (GCSD) can enhance the surface properties of zirconia, its biological effects remain unclear. In this study, the biological responses of human osteoblast-like (MG-63) cells to GCSD-modified zirconia surfaces were evaluated to assess the potential application in zirconia abutments. Disk-shaped zirconia and titanium alloy samples were prepared; titanium served as the control (Ti). Zirconia was subjected to polishing (NT), airborne-particle abrasion (AB), or GCSD with (GE) or without (GC) hydrofluoric acid (HF) etching. Surface characteristics, including wettability, surface energy (SE), and surface potential (SP), were analyzed. Cytotoxicity and MG-63 cell adhesion were assessed using the PrestoBlue assay, scanning electron microscopy (SEM), viability staining, and confocal laser scanning microscopy (CLSM). Statistical analysis was performed with a significance level of 0.05. GCSD produced a dense glass-ceramic coating on the zirconia surface, which significantly enhanced hydrophilicity as indicated by reduced water contact angles and increased SE in the GC and GE groups (

Indexed as

abutmentscell behaviordental restorationglass-ceramiclive/dead stainingspray depositionzirconia

Identifiers

PMID40863308
PMCPMC12387143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.