Evidence map›Paper›PMID 40863301›Full record

ArticleJournal of functional biomaterials2025

The Effect of Collagen Membrane Fixation with Pins on Buccal Bone Regeneration in Immediate Dental Implant Sites: A Preclinical Study in Dogs.

Yuma Hazama, Takahisa Iida, Niklaus P Lang, Fernando M Muñoz Guzon, Giovanna Iezzi, Daniele Botticelli, Shunsuke Baba

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuma HazamaDepartment of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.
Takahisa IidaDepartment of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.
Niklaus P LangDepartment of Periodontology, University of Berne, 3010 Bern, Switzerland.
Fernando M Muñoz GuzonIbonelab, Centro de Empresas e Innovación Nodus, 27003 Lugo, Spain.ORCID 0000-0002-4130-1526
Giovanna IezziDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66013 Chieti, Italy.
Daniele BotticelliDepartment of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.ORCID 0000-0003-2804-1632
Shunsuke BabaDepartment of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.

Funding

ARDEC Academy, Riccione Italy NA
6 · The paper itself

Abstract

backgroundThe role of collagen membrane fixation during guided bone regeneration (GBR) remains debatable, particularly in post-extraction sockets with buccal defects and concomitant immediate implant placement. This study evaluated whether or not fixation with titanium pins improved regenerative outcomes.

methodsSix adult Beagle dogs received bilateral extractions of the fourth mandibular premolars. An implant was immediately placed in both the distal alveoli, and standardized buccal bone defects (5 mm height, 3-2 mm width) were prepared. All defects were filled with a slowly resorbing equine xenograft and covered by a resorbable pericardium membrane. At the test sites, the membrane was apically fixed with pins, while no fixation was applied to the control sites. After 3 months of healing, histomorphometric analyses were performed.

resultsThe vertical bone gain of the buccal crest was 3.2 mm in the test sites (pin group) and 2.9 mm in the control sites (no-pin) (

conclusionsMembrane fixation did not significantly enhance vertical bone gain, and although the slightly higher regeneration in the pin group (3.2 mm vs. 2.9 mm) may hold clinical relevance in esthetically sensitive areas and osseointegration, it appeared to limit apical migration of the grafting material.

Indexed as

artificial + collagenbiocompatible materialsbone regenerationbone substitutesbone transplantationhistological techniquesmembranesoperativesurgical procedurestooth extraction

Identifiers

PMID40863301
PMCPMC12387244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.