Evidence map›Paper›PMID 40863208›Full record

ReviewDiseases (Basel, Switzerland)2025

Endoscopic Ultrasound (EUS) in Gastric Cancer: Current Applications and Future Perspectives.

Dimitrios I Ziogas, Nikolaos Kalakos, Anastasios Manolakis, Theodoros Voulgaris, Ioannis Vezakis, Mario Tadic, Ioannis S Papanikolaou

Abstract readReview
In one paragraph

Review in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dimitrios I ZiogasDepartment of Gastroenterology, Athens Naval Hospital, 11521 Athens, Greece.ORCID 0009-0003-3103-2638
Nikolaos KalakosDepartment of Gastroenterology, General Hospital of Athens "G. Gennimatas", 11527 Athens, Greece.ORCID 0009-0009-1606-5232
Anastasios ManolakisDepartment of Gastroenterology, University Hospital of Larisa, 41110 Larisa, Greece.
Theodoros VoulgarisAcademic Department of Gastroenterology, Medical School of National and Kapodistrian, University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0000-0002-8383-825X
Ioannis VezakisBiomedical Engineering Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens, Zografou Polytechnic Campus, 15772 Athens, Greece.ORCID 0000-0003-4976-4901
Mario TadicDepartment of Gastroenterology, Hepatology and Clinical Nutrition, Faculty of Pharmacy and Biochemistry, University of Zagreb, Clinical Hospital Dubrava, 10040 Zagreb, Croatia.ORCID 0000-0001-7494-2605
Ioannis S PapanikolaouHepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-7368-6168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer remains the fourth leading cause of cancer-related mortality worldwide. Advanced disease is associated with a poor prognosis, emphasizing the critical importance of early diagnosis through endoscopy. In addition to prognosis, disease extent also plays a pivotal role in guiding management strategies. Therefore, accurate locoregional staging (T and N staging) is vital for optimal prognostic and therapeutic planning. Endoscopic ultrasound (EUS) has long been an essential tool in this regard, with computed tomography (CT) and, more recently, positron emission tomography-computed tomography (PET-CT) serving as alternative imaging modalities. EUS is particularly valuable in the assessment of early gastric cancer, defined as tumor invasion confined to the mucosa or submucosa. These tumors are increasingly managed by endoscopic resection techniques offering improved post-treatment quality of life. EUS has also recently been utilized in the restaging process after neoadjuvant chemotherapy, aiding in the evaluation of tumor resectability and prognosis. Its performance may be further enhanced through the application of emerging techniques such as contrast-enhanced endosonography, EUS elastography, and artificial intelligence systems. In advanced, unresectable disease, complications such as gastric outlet obstruction (GOO) severely impact patient quality of life. In this setting, EUS-guided gastroenterostomy (EUS-GE) offers a less invasive alternative to surgical gastrojejunostomy. This review summarizes and critically analyzes the role of EUS in the context of gastric cancer, highlighting its applications across different stages of the disease and evaluating its performance relative to other diagnostic modalities.

Indexed as

endosonography gastric cancerEUS-guided gastroenterostomygastric cancer EUS staginggastric cancer stagingminiprobe EUS

Identifiers

PMID40863208
PMCPMC12385178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.