Evidence map›Paper›PMID 40863101›Full record

ReviewClinics and practice2025

Cognitive Impairment in Adult Attention Deficit Hyperactivity Disorder: Clinical Implications and Novel Treatment Strategies.

Alexis J Vega, Gabriel V Hernandez, Ahmed I Anwar, Bahareh Sharafi, Rahib K Islam, Sahar Shekoohi, Alan D Kaye

Abstract readReview
In one paragraph

Review in Clinics and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexis J VegaSchool of Medicine, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA.
Gabriel V HernandezSchool of Medicine, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA.
Ahmed I AnwarDepartment of Psychology, Quinnipiac University, 275 Mount Carmel Ave, Hamden, CT 06518, USA.ORCID 0000-0002-3140-357X
Bahareh SharafiPsychiatry Department, Citrus Health Herbert Wetheim College of Medicine, 4175 W 20th Ave, Hialeah, FL 33012, USA.ORCID 0000-0003-3807-8826
Rahib K IslamSchool of Medicine, Louisiana State University Health and Sciences Center in New Orleans, New Orleans, LA 70112, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71103, USA.ORCID 0009-0007-4545-4523
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0003-2464-0187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a lifelong condition; however, traditional treatment focuses on hyperactivity and inattention, which is largely a manifestation of pediatric ADHD. Studies are limited regarding cognitive difficulties, as seen in adult ADHD, as well as treatment strategies for this population. This review of the literature examines multiple recent studies that discuss various novel treatment strategies for cognitive impairment in adults with ADHD. A targeted literature review was conducted using PubMed to identify recent studies on cognitive dysfunction in adults with ADHD, with an emphasis on emerging treatment strategies. Data collected included sample size, intervention strategies, cognitive function, and side effects. Studies on non-invasive brain stimulation revealed significant effects on executive function in adult ADHD patients. Other studies revealed statistically significant improvements in cognitive flexibility and response inhibition in modafinil users. Another study demonstrated significant improvement in working memory with off label use of viloxazine for adults. This review of the literature describes the effectiveness of novel treatment strategies of adult ADHD including non-stimulant medications, behavioral therapies and neurofeedback. This highlights the need for treatment modalities that enhance cognitive outcomes and further research into long-term efficacy and safety of these novel interventions and implementing psychological treatment into medical management of adult ADHD.

Indexed as

adult deficit hyperactivity disorder (ADHD)adultscognitioncognitive behavioral therapy (CBT)dialectical behavioral therapy (DBT)modafinilneurofeedbackviloxazine

Identifiers

PMID40863101
PMCPMC12384060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.