Evidence map›Paper›PMID 40863006›Full record

ArticleBiosensors2025

Towards an Implantable Aptamer Biosensor for Monitoring in Inflammatory Bowel Disease.

Yanan Huang, Wenlu Duan, Fei Deng, Wenxian Tang, Sophie C Payne, Tianruo Guo, Ewa M Goldys, Nigel H Lovell, Mohit N Shivdasani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanan HuangGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.ORCID 0000-0002-0509-7433
Wenlu DuanGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.
Fei DengGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.
Wenxian TangGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.
Sophie C PayneBionics Institute, Melbourne 3065, Australia.ORCID 0000-0002-3428-2275
Tianruo GuoGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.
Ewa M GoldysGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.
Nigel H LovellGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.ORCID 0000-0003-1637-1079
Mohit N ShivdasaniGraduate School of Biomedical Engineering, UNSW Sydney, Sydney 2052, Australia.ORCID 0000-0002-0692-4971

Funding

Merck Bioelectronics KGaA, Darmstadt, Germany No grant number
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a relapsing-remitting condition resulting in chronic inflammation of the gastrointestinal tract. Present methods are either inadequate or not viable for continuous tracking of disease progression in individuals. In this study, we present the development towards an implantable biosensor for detecting interleukin-6 (IL-6), an important cytokine implicated in IBD. The optimised sensor design includes a gold surface functionalised with a known IL-6-specific aptamer, integrating a recognition sequence and an electrochemical redox probe. The IL-6 aptasensor demonstrated a sensitivity of up to 40% and selectivity up to 10% to the IL-6 target in vitro. Sensors were found to degrade over 7 days when exposed to recombinant IL-6, with the degradation rate rapidly increasing when exposed to intestinal mucosa. A feasibility in vivo experiment with a newly designed implantable gut sensor array confirmed rapid degradation over a 5-h implantation period. We achieved up to a 93% reduction in sensor degradation rates, with a polyvinyl alcohol-methyl acrylate hydrogel coating that aimed to reduce nonspecific interactions in complex analytes compared to uncoated sensors. Degradation was linked to desorption of the monolayer leading to breakage of gold thiol bonds. While there are key challenges to be resolved before a stable implantable IBD sensor is realised, this work highlights the potential of aptamer-based biosensors as effective tools for long-term diagnostic monitoring in IBD.

Indexed as

Aptamers, NucleotideBiosensing TechniquesInflammatory Bowel DiseasesInterleukin-6AnimalsGoldHumansProstheses and ImplantsSurface PropertiesAptamers, NucleotideGoldInterleukin-6aptamerbiosensorcytokinehydrogelinflammatory bowel diseaseinterleukin-6

Identifiers

PMID40863006
PMCPMC12384986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.