Simultaneous Routing with Washing Droplets Based on Shape-Dependent Velocity Model in MEDA Biochips.

Chiharu Shiro, Hiroki Nishikawa, Xiangbo Kong, Hiroyuki Tomiyama, Shigeru Yamashita

Abstract read

In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chiharu ShiroGraduate School of Science and Engineering, Ritsumeikan University, Kusatsu 525-8577, Japan.

Hiroki NishikawaGraduate School of Information Science and Technology, The University of Osaka, Suita 565-0871, Japan.ORCID 0000-0002-9626-0944

Xiangbo KongDepartment of Intelligent Robotics, Faculty of Information Engineering, Toyama Prefectural University, Imizu 939-0398, Japan.

Hiroyuki TomiyamaGraduate School of Science and Engineering, Ritsumeikan University, Kusatsu 525-8577, Japan.

Shigeru YamashitaCollege of Information Science and Engineering, Ritsumeikan University, Suita 567-8570, Japan.ORCID 0000-0002-2279-4644

Funding

Japan Society for the Promotion of Science 23K20378

6 · The paper itself

Abstract

Micro Electrode Dot Array (MEDA) biochips have recently attracted considerable attention in the biochemical and medical industries. MEDA biochips manipulate micro droplets for biochemical experiments such as DNA analysis. Droplets on MEDA biochips are moved using the Electrowetting on Dielectric (EWOD) effect, but a portion of a droplet may remain on a cell after passing through, contaminating the cell. Other droplets cannot pass through a contaminated cell. In previous studies, contaminated cells were considered unavailable for droplet routing. As the number of contaminated cells increases, droplets may be prevented from moving to the desired position. Therefore, we propose a method for simultaneous routing of target functional and washing droplets based on a shape-dependent velocity model. In a simulation, the proposed method reduced the routing time by about 10% compared with an existing method.

Indexed as

Biosensing TechniquesElectrodesElectrowettingbiochipsdigital microfluidicsdroplet routingmathematical programming problemMEDA

Identifiers

PMID40862993

DOI10.3390/bios15080533

PMCPMC12385100

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.