ArticleBiosensors2025
Development and Characterisation of a Microneedle Sensor for Intrapartum Fetal Monitoring.
Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
This study presents the in vitro and preliminary ex vivo development of a novel microneedle-based pH sensor for continuous intrapartum fetal monitoring. The objective was to evaluate the feasibility of using microneedle sensors to monitor fetal pH during labour and to develop a proof-of-principle microneedle pH sensor that meets clinical requirements such as high sensitivity to small pH changes (0.05 units) within a relevant range (6.50-7.45), minimal tissue disruption, and a compact design suitable for transcervical placement on the fetal scalp (<40 mm diameter). Platinum microneedles were passivated with ArCare medical adhesive and coated with iridium oxide via electrodeposition. Sensitivity was tested in phosphate buffered saline (PBS) and artificial interstitial fluid (ISF), using both external Ag/AgCl and internal platinum pseudo-reference electrodes. In PBS, the sensor exhibited linear responses in increments of 0.05 pH units over the clinically relevant range (6.5-7.45), with slopes of -60.49 mV/pH (R
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