ArticleBiosensors2025
Fiber-Based Ultra-High-Speed Diffuse Speckle Contrast Analysis System for Deep Blood Flow Sensing Using a Large SPAD Camera.
Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation.Journal of biomedical optics · 2026Article
- Assessing liquid light guides in diffuse correlation spectroscopy systems.Biomedical optics express · 2025Article
- On-skin, micro-objective enabled camera module for speckle contrast optical spectroscopy/tomography.Biomedical optics express · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
Diffuse speckle contrast analysis (DSCA), also called speckle contrast optical spectroscopy (SCOS), has emerged as a groundbreaking optical imaging technique for tracking dynamic biological processes, including blood flow and tissue perfusion. Recent advancements in single-photon avalanche diode (SPAD) cameras have unlocked exceptional sensitivity, time resolution, and high frame-rate imaging capabilities. Despite this, the application of large-format SPAD arrays in speckle contrast analysis is still relatively uncommon. This study introduces a pioneering use of a large-format SPAD camera for DSCA. By harnessing the camera's high temporal resolution and photon-detection efficiency, we significantly enhance the accuracy and robustness of speckle contrast measurements. Our experimental results demonstrate the system's remarkable ability to capture rapid temporal variations over a broad field of view, enabling detailed spatiotemporal analysis. Through simulations, phantom experiments, and in vivo studies, we validated the proposed approach's potential for cerebral blood flow and functional tissue monitoring. This work highlights the transformative impact of large SPAD cameras on DSCA, setting the stage for breakthroughs in optical imaging.
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Registered trials
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