Evidence map›Paper›PMID 40862969›Full record

ArticleBiosensors2025

Dual-Emission Au-Ag Nanoclusters with Enhanced Photoluminescence and Thermal Sensitivity for Intracellular Ratiometric Nanothermometry.

Helin Liu, Zhongliang Zhou, Zhiwei Wang, Jianhai Wang, Yu Wang, Lu Huang, Tianhuan Guo, Rongcheng Han, Yuqiang Jiang

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Helin LiuLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Zhongliang ZhouInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0003-1756-7540
Zhiwei WangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Jianhai WangSingle-Molecule and Nanobiology Laboratory, Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University, Beijing 100083, China.
Yu WangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Lu HuangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Tianhuan GuoChina Union of Life Science Societies, Beijing 100101, China.
Rongcheng HanInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-5058-3932
Yuqiang JiangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0009-0002-0744-4336

Funding

the National Key R&D Program of China 2024YFA1209900, 2024YFA1209901, 2024YFA120990
6 · The paper itself

Abstract

We report the development of highly luminescent, bovine serum albumin (BSA)-stabilized gold-silver bimetallic nanoclusters (Au-AgNCs@BSA) as a novel platform for high-sensitivity, ratiometric intracellular temperature sensing. Precise and non-invasive temperature sensing at the nanoscale is crucial for applications ranging from intracellular thermogenesis monitoring to localized hyperthermia therapies. Traditional luminescent thermometric platforms often suffer from limitations such as high cytotoxicity and low photostability. Here, we synthesized Au-AgNCs@BSA via a one-pot aqueous reaction, achieving significantly enhanced photoluminescence quantum yields (PL QYs, up to 18%) and superior thermal responsiveness compared to monometallic counterparts. The dual-emissive Au-AgNCs@BSA exhibit a linear ratiometric fluorescence response to temperature fluctuations within the physiological range (20-50 °C), enabling accurate and concentration-independent thermometry in live cells. Time-resolved PL and Arrhenius analyses reveal two distinct emissive states and a high thermal activation energy (

Indexed as

Biosensing TechniquesGoldMetal NanoparticlesSilverThermometryAnimalsCattleHumansLuminescenceSerum Albumin, BovineTemperatureGoldSerum Albumin, BovineSilverbimetallic nanoclustersintracellular temperature sensingratiometric nanothermometer

Identifiers

PMID40862969
PMCPMC12384061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.