Evidence map›Paper›PMID 40862964›Full record

ReviewBiosensors2025

Synthesis and Biomedical Applications of PLA-HPG-Based Biodegradable Nanocarriers: A Review.

Yijun Shen, Xuehan He, Lei Chen

Abstract readReview
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yijun ShenGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
Xuehan HeSchool of Pharmaceutical Sciences (Shenzhen Campus), Sun Yat-sen University, Shenzhen 518107, China.
Lei ChenGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.ORCID 0000-0001-6935-8340

Funding

Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province 2020B1212060077Natural Science Foundation of Guangdong Province 2025A1515010401Natural Science Foundation of Shenzhen City JCYJ20240813151023030
6 · The paper itself

Abstract

The development of biodegradable nanocarriers has long been a priority for researchers and medical professionals in the realm of drug delivery. Because of their inherent benefits, which include superior biocompatibility, customizable degradability, easy surface functionalization, and stealth-like behavior, polylactic acid-hyperbranched polyglycerol (PLA-HPG) copolymers have demonstrated a promising future in the field of biomedical research. The synthesis of PLA-HPG copolymers and the creation of their nanoparticles for biomedical uses have been the focus of current efforts. In this review, we summarize the synthetic strategies of PLA-HPG copolymers and corresponding nanoparticles, and highlight their physicochemical properties, biocompatibility, and degradation properties. Furthermore, we introduce a number of PLA-HPG nanoparticles that are utilized for surface skin delivery, wound dressing, and in vivo drug delivery biological applications. Finally, we conclude by offering our thoughts on how this nanoplatform might advance in the future.

Indexed as

Biocompatible MaterialsDrug CarriersGlycerolNanoparticlesPolyestersPolymersAnimalsDrug Delivery SystemsHumansBiocompatible MaterialsDrug CarriersGlycerolPolyesterspolyglycerolpoly(lactide)Polymersbiodegradable nanocarriersdrug deliveryPLA-HPGsunblockwound dressing

Identifiers

PMID40862964
PMCPMC12384396

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.