Evidence map›Paper›PMID 40862923›Full record

ArticleBiomimetics (Basel, Switzerland)2025

Hyaluronic-Acid-Coated Sterosome for Dasatinib Delivery in Hepatocellular Carcinoma: Preparation, Physicochemical Characterization, and In Vitro Evaluation.

Chae Yeong Lee, Jeong Min Lee, Chung-Sung Lee, Hee Sook Hwang

Abstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chae Yeong LeeDepartment of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Republic of Korea.
Jeong Min LeeDepartment of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Republic of Korea.
Chung-Sung LeeDepartment of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.
Hee Sook HwangDepartment of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Republic of Korea.ORCID 0009-0000-0572-5586

Funding

Ministry of Science and ICT RS-2024-00334037Soonchunhyang University N/A
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and treatment remains challenging due to high recurrence rates, resistance to chemotherapy, and severe side effects. Dasatinib (Das) has shown therapeutic potential against HCC, but its clinical use is limited by poor bioavailability and short half-life (~3-4 h). Here, we developed a hyaluronic acid (HA)-coated sterosome for targeted and sustained delivery of Das to CD44-overexpressing HCC cells. Sterosomes composed of octadecylamine and cholesterol at a 5:5 (

Indexed as

CD44 targetingdasatinibhepatocellular carcinomahyaluronic acidsterosome

Identifiers

PMID40862923
PMCPMC12383443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.