Evidence map›Paper›PMID 40862841›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Real-World Effectiveness and Safety of Immune Checkpoint Inhibitors Combined with Chemotherapy in Taiwanese Patients with Extensive-Stage Small Cell Lung Cancer.

Cheng-Yu Chang, Yu-Feng Wei, Shih-Chieh Chang, Chung-Yu Chen

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cheng-Yu ChangDivision of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan.
Yu-Feng WeiDepartment of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445, Taiwan.
Shih-Chieh ChangDivision of Chest Medicine, Department of Internal Medicine, National Yang Ming Chiao Tung University Hospital, Yilan 260006, Taiwan.ORCID 0009-0006-4470-1783
Chung-Yu ChenDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin County 64002, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExtensive-stage small cell lung cancer (ES-SCLC) has poor prognosis. While immune checkpoint inhibitors (ICIs) with chemotherapy show survival benefits in trials, real-world data from Asia are scarce. This study evaluates real-world efficacy and safety of chemotherapy with or without ICIs in Taiwanese patients with ES-SCLC and identifies survival predictors. MATERIALS AND

methodsA retrospective cohort study analyzed 114 patients with ES-SCLC treated between 2017 and 2023 at four Taiwanese medical centers. Patients received first-line chemotherapy alone (

resultsBaseline characteristics were comparable, except poorer ECOG performance (≥2) in the chemotherapy group (27% vs. 9%;

conclusionImmunochemotherapy significantly improves survival in Taiwanese patients with ES-SCLC, with manageable toxicity, supporting ICIs' incorporation into standard treatment.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsImmune Checkpoint InhibitorsLung NeoplasmsSmall Cell Lung CarcinomaAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesTaiwanTreatment OutcomeImmune Checkpoint Inhibitorschemotherapyimmunotherapyreal-worldsmall cell lung cancersurvival

Identifiers

PMID40862841
PMCPMC12384557

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.