Evidence map›Paper›PMID 40862829›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

Practical Guidance for the Expanded Implementation and Provision of Bispecific Antibodies for Diffuse Large B-Cell Lymphoma (DLBCL) Across Canada.

David MacDonald, Robert Puckrin, Pamela Skrabek, Selay Lam, Jai Jayakar, Isabelle Fleury, Christopher Lemieux, Mélina Boutin, Jacqueline Costello

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David MacDonaldDivision of Hematology, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Robert PuckrinArthur J.E. Child Comprehensive Cancer Centre, Calgary, AB T2N 5G2, Canada.
Pamela SkrabekSection of Medical Oncology/Hematology, Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3A TR9, Canada.
Selay LamDivision of Hematology, Department of Medicine, Western University, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Jai JayakarDivision of Hematology, Department of Medicine, Southlake Health, Newmarket, ON L3Y 2P9, Canada.
Isabelle FleuryHematology-Oncology and Cell Therapy University Institute, Hôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, Canada.
Christopher LemieuxDivison of Hemato-Oncology and Transplantation, CHU de Québec-Université, Laval, QC G1V 0E8, Canada.ORCID 0000-0002-0281-5866
Mélina BoutinDivision of Hemato-Oncology, Charles-Lemoyne Research Center, Greenfield Park, QC J4V 2G9, Canada.
Jacqueline CostelloFaculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada.

Funding

Roche (Canada) N/A
6 · The paper itself

Abstract

(1) Background: Bispecific antibodies (BsAbs) for the treatment of relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) can be delivered in ambulatory healthcare settings; however, the safe and effective management of potential side effects, such as cytokine release syndrome (CRS), requires protocolized monitoring and management. (2) Methods: An Expert Working Group (EWG) of nine hematologists from across Canada, with experience in leading BsAb program implementation, combined a review of published literature, a comparison of national/provincial/regional guidance documents and protocols, and their professional experiences to produce an informed framework for BsAb program implementation in various healthcare settings. (3) Results: The EWG supports and recommends the progression of BsAb provision from predominantly inpatient hospital settings to community/ambulatory care settings closer to the patient's home. A seven-step implementation process is outlined to support the safe and effective establishment of such programs, from establishing leadership, through customization of protocols, to education and execution. Strategies and considerations are offered to overcome potential barriers and empower healthcare professionals who are working to establish or improve BsAb programs across Canada. (4) Conclusions: For patients with R/R DLBCL, the safe and effective provision of BsAbs closer to home is both feasible and preferred. This guidance is intended to support the efficient and effective setup or enhancement of BsAb programs in lymphoma.

Indexed as

Antibodies, BispecificLymphoma, Large B-Cell, DiffuseCanadaHumansAntibodies, Bispecificbispecific antibodiesdiffuse large B-cell lymphomaepcoritamabglofitamabodronextamabrelapsed refractory lymphomaT-cell engaging therapy

Identifiers

PMID40862829
PMCPMC12384478

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.