Evidence map›Paper›PMID 40862814›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Impact of Surgical Margin Control in Index Tumors on Prognosis After Radical Prostatectomy: A Focus on Zonal Origin.

Jun Akatsuka, Yoshihiko Ogata, Kotaro Obayashi, Mami Takadate, Shunsuke Ikuma, Hiroya Hasegawa, Hikaru Mikami, Hayato Takeda, Yuki Endo, Takayuki Takahashi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jun AkatsukaDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Yoshihiko OgataDepartment of Urology, Nippon Medical School Tama Nagayama Hospital, Tokyo 206-8512, Japan.
Kotaro ObayashiDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Mami TakadateDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Shunsuke IkumaDepartment of Urology, Nippon Medical School Tama Nagayama Hospital, Tokyo 206-8512, Japan.ORCID 0009-0006-0570-8173
Hiroya HasegawaDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Hikaru MikamiDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Hayato TakedaDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0000-0002-4556-6601
Yuki EndoDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0009-0002-0787-9321
Takayuki TakahashiPathology Informatics Team, RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.ORCID 0000-0002-3457-0031
Kaori OnoPathology Informatics Team, RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.
Yuka ToyamaDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Yoichiro YamamotoPathology Informatics Team, RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.
Go KimuraDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0000-0003-0088-9324
Yukihiro KondoDepartment of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0000-0003-4141-9230

Funding

JST Moonshot R&D JPMJMS2022MEXT KAKENHI 23K17235
6 · The paper itself

Abstract

We investigated the clinical significance of positive surgical margins (PSMs) in index tumors following radical prostatectomy (RP), with particular attention to the tumor's zonal origin. Among 1148 patients with localized prostate cancer who underwent RPs, 973 were included after excluding those who received perioperative therapy or had incomplete data. Index tumors were categorized by zonal origin: transition zone, peripheral zone, or central zone (CZ). Overall, PSMs were observed in 26.4% of index tumors. Although CZ index tumors were relatively uncommon (6.5%), they exhibited the highest PSM rate (42.9%) and showed the most aggressive pathological features. The 5-year biochemical recurrence (BCR)-free survival rate was significantly lower in patients with PSMs in index tumors than in those with negative surgical margins (45.6% vs. 86.8%,

Indexed as

Margins of ExcisionProstatectomyProstatic NeoplasmsAgedDisease-Free SurvivalHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective Studiesindex tumorprostatectomyprostatic neoplasmssurgical margin

Identifiers

PMID40862814
PMCPMC12385668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.