Evidence map›Paper›PMID 40862812›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

A Review on the Evolving Role of Radiation Therapy in the Treatment of Locally Advanced Rectal Cancer.

Zeinab Dandash, Tala Mobayed, Sally Temraz, Ali Shamseddine, Samer Doughan, Samer Deeba, Zeina Ayoub, Toufic Eid, Bassem Youssef, Lara Hilal

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeinab DandashDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.ORCID 0009-0000-2975-2597
Tala MobayedDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.ORCID 0000-0001-9113-9769
Sally TemrazDepartment of Hematology-Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.ORCID 0000-0002-8995-7946
Ali ShamseddineDepartment of Hematology-Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.ORCID 0000-0003-3725-8403
Samer DoughanDepartment of Surgery, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Samer DeebaDepartment of Surgery, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Zeina AyoubDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Toufic EidDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Bassem YoussefDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.ORCID 0000-0003-3960-8155
Lara HilalDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.ORCID 0000-0002-4508-2391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of locally advanced rectal cancer (LARC), clinical stages II-III, typically involves multimodal treatment options. Over the past decade, the role of radiation therapy as a neoadjuvant treatment for LARC has evolved and is currently a part of total neoadjuvant therapy (TNT). Some recently published studies advocate for the omission of radiation therapy entirely, while others report on a non-operative approach that emphasizes the use of higher radiation therapy doses. This review aims to evaluate the latest literature on the current role of radiation therapy in the management of LARC, with a discussion of how to best select the most appropriate treatment protocol based on individual patient and tumor characteristics, comorbidities, and personal needs and preferences.

Indexed as

Rectal NeoplasmsHumansNeoadjuvant Therapylocally advanced rectal cancernon-operative managementomission of RTpersonalized treatmentshort- versus long-course chemoradiationtotal neoadjuvant therapy

Identifiers

PMID40862812
PMCPMC12385660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.