Evidence map›Paper›PMID 40862765›Full record

ArticleCells2025

Mutation of MeCP2 at T158M Leads to Distinct Molecular and Phenotypic Abnormalities in Male and Female Mice.

Chris-Tiann Roberts, Ashraf Kadar Shahib, Khatereh Saei Arezoumand, Ghanan Bin Akhtar, Kazem Nejati-Koshki, Jessica S Jarmasz, Seyyed Mohyeddin Ziaee, Marjorie Buist, Nicole Raabe, Abbas Rezaeian Mehrabadi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chris-Tiann RobertsBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.ORCID 0009-0002-8872-5542
Ashraf Kadar ShahibBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.ORCID 0009-0009-8641-7969
Khatereh Saei ArezoumandBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Ghanan Bin AkhtarBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Kazem Nejati-KoshkiBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Jessica S JarmaszBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Seyyed Mohyeddin ZiaeeBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Marjorie BuistBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Nicole RaabeBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Abbas Rezaeian MehrabadiBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Carl O OlsonBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.
Mojgan RastegarBiochemistry and Medical Genetics, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, 745 Bannatyne Avenue, Basic Medical Sciences Bldg. Room 627, Winnipeg, MB R3E 0J9, Canada.ORCID 0000-0003-3619-6116

Funding

Canadian Institutes of Health Research (CIHR) Project Grant Project Grant 202209PJT-486512-CIA-CDAA-111824Children's Hospital Research Institute of Manitoba (CHRIM) Operating GrantNatural Sciences and Engineering Research Council of Canada Discovery Grant (NSERC-DG) #RGPIN-2024-04920Ontario Rett Syndrome Association (ORSA) Hope Fund
6 · The paper itself

Abstract

Methyl CpG-binding protein 2 (MeCP2) is an epigenetic reader of DNA methylation with high abundance in the brain. While genetic mutations occur across different protein domains of MeCP2, the T158M mutation is amongst the most frequent MeCP2 mutations. MeCP2 is encoded by the

Indexed as

Methyl-CpG-Binding Protein 2MutationRett SyndromeAnimalsBrainDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicPhenotypeMecp2 protein, mouseMethyl-CpG-Binding Protein 2brain developmentDNA methylationepigeneticsMeCP2 mutationneurodevelopmental disordersRett Syndrometransgenic mice

Identifiers

PMID40862765
PMCPMC12384606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.