Evidence map›Paper›PMID 40862738›Full record

ArticleCells2025

Highly Oligomeric DRP1 Strategic Positioning at Mitochondria-Sarcoplasmic Reticulum Contacts in Adult Murine Heart Through ACTIN Anchoring.

Celia Fernandez-Sanz, Sergio De la Fuente, Zuzana Nichtova, Marilen Federico, Stephane Duvezin-Caubet, Sebastian Lanvermann, Hui-Ying Tsai, Yanguo Xin, Gyorgy Csordas, Wang Wang and 2 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Celia Fernandez-SanzCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-0809-0675
Sergio De la FuenteCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Zuzana NichtovaMitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy & Cell Biol., Thomas Jefferson University, Philadelphia, PA 19107, USA.
Marilen FedericoCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Stephane Duvezin-CaubetUniversity of Bordeaux, CNRS, IBGC, UMR 5095, F-33000 Bordeaux, France.ORCID 0000-0002-0243-2697
Sebastian LanvermannCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Hui-Ying TsaiCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-1328-9726
Yanguo XinMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA.
Gyorgy CsordasMitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy & Cell Biol., Thomas Jefferson University, Philadelphia, PA 19107, USA.
Wang WangMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0001-9093-412X
Arnaud MourierUniversity of Bordeaux, CNRS, IBGC, UMR 5095, F-33000 Bordeaux, France.ORCID 0000-0002-5413-611X
Shey-Shing SheuCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-3838-3601

Funding

Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0M
Dynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics CouplingR01HL137266 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SHEU, SHEY-SHING, WANG, WANG · 2018 to 2021
$2.5M
Structural-functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulationR01HL142864 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2018 to 2021
$2.5M
Vevo 3100 ultrasound scanner and PV loop systemS10OD030483 · OD · THOMAS JEFFERSON UNIVERSITY · PI FORSBERG, FLEMMING · 2021 to 2021
$747k
Regulation and function of mitochondrial calcium uniporter in the heartR56HL153124 · NHLBI · UNIVERSITY OF WASHINGTON · PI WANG, WANG · 2022 to 2022
$736k
Optimice 100-Cage IVC SystemS15OD039813 · OD · THOMAS JEFFERSON UNIVERSITY · PI LATOURETTE, PHIL · 2025 to 2025
$348k
NHLBI NIH HHS R01 HL122124NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R01 HL142864NHLBI NIH HHS R56 HL153124NIH HHS 5R01HL137266-03NIH HHS S10 OD030483NIH HHS S15 OD039813
6 · The paper itself

Abstract

Mitochondrial fission and fusion appear to be relatively infrequent in cardiac cells compared to other cell types; however, the proteins involved in these events are highly expressed in adult cardiomyocytes (ACM). Therefore, these proteins likely have additional non-canonical roles. We have previously shown that DRP1 not only participates in mitochondrial fission processes but also regulates mitochondrial bioenergetics in cardiac tissue. However, it is still unknown where the DRP1 that does not participate in mitochondrial fission is located and what its role is at those non-fission spots. Therefore, this manuscript will clarify whether oligomeric DRP1 is located at the SR-mitochondria interface, a specific region that harbors the Ca

Indexed as

ActinsDynaminsMitochondriaMitochondria, HeartMyocardiumSarcoplasmic ReticulumAnimalsCalciumMaleMiceMice, Inbred C57BLMitochondrial DynamicsMyocytes, CardiacActinsCalciumDnm1l protein, mouseDynaminsadult cardiomyocytes (ACM)DRP1 oligomersdynamin-related protein 1 (DRP1)high Ca2+ microdomainsmitochondria-associated membranes (MAM)sarcoplasmic reticulum (SR)β-ACTIN

Identifiers

PMID40862738
PMCPMC12384166

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.