Evidence map›Paper›PMID 40862732›Full record

ArticleCells2025

Investigation and Distinction of Energy Metabolism in Proliferating Hepatocytes and Hepatocellular Carcinoma Cells.

Julia Nerusch, Gerda Schicht, Natalie Herzog, Jan-Heiner Küpper, Daniel Seehofer, Georg Damm

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julia NeruschDepartment of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.
Gerda SchichtDepartment of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-2799-6210
Natalie HerzogFaculty of Science, Brandenburg University of Technology Cottbus-Senftenberg, 01968 Senftenberg, Germany.
Jan-Heiner KüpperFaculty of Science, Brandenburg University of Technology Cottbus-Senftenberg, 01968 Senftenberg, Germany.ORCID 0000-0002-6526-8433
Daniel SeehoferDepartment of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-7492-8309
Georg DammDepartment of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-2104-8076

Funding

Federal Ministry of Education and Research (BMBF, Germany) within the research net-work Liver Systems Medicine (LiSyM) Cancer: DEEP-HCC 031L0258E and 031L0315DFederal Ministry of Education and Research (BMBF, Germany) within the research net-work Liver Systems Medicine (LiSyM) Cancer: SMART-NAFLD 031L0256C and 031L0313Cthe Medical Faculty of Leipzig University, 990101-113
6 · The paper itself

Abstract

Metabolic rewiring is a hallmark of both hepatic regeneration and malignant transformation, complicating the identification of cancer-specific traits. This study aimed to distinguish the metabolic profiles of proliferating hepatocytes and hepatocellular carcinoma (HCC) cells through integrated analyses of mRNA and protein expression, along with functional characterization. We compared non-malignant Upcyte

Indexed as

Carcinoma, HepatocellularEnergy MetabolismHepatocytesLiver NeoplasmsCell Line, TumorCell ProliferationGlycolysisHumansBDH1c-MYCglycolysisHepaFH3hepatocellular carcinomaHIF1Aketone body metabolismliver regenerationmetabolic reprogrammingtumor markers

Identifiers

PMID40862732
PMCPMC12384642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.