Evidence map›Paper›PMID 40862675›Full record

ArticleJournal of molecular cell biology2026

African swine fever virus DEAD-box helicase D1133L promotes OGG1-driven incision of genomic 8-oxoG via HDAC5 deacetylation.

Jie Fan, Jifei Yang, Zhancheng Tian, Xiaoqiang Zhang, Shuxian Geng, Jianxun Luo, Istvan Boldogh, Qiaoying Zeng, Hong Yin, Guiquan Guan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie FanState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.ORCID 0000-0003-0142-9653
Jifei YangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Zhancheng TianState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Xiaoqiang ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Shuxian GengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Jianxun LuoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Istvan BoldoghDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Qiaoying ZengCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Hong YinState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Guiquan GuanState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Qingli NiuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.

Funding

Central Public-interest Scientific Institution Basal Research Fund, CAFS CAAS-ZDRW202409Fundamental Research Funds for the Central Universities 31920230184National Agricultural Science and Technology Innovation Program CAAS-ASTIP-2021-LVRINational Key Research and Development Program 2021YFD1800101National Natural Science Foundation of China 32072830National Natural Science Foundation of China U24A20450Natural Science Foundation of Gansu 24JRRA011Science and Technology Development 22ZD6NA001Science Fund for Creative Research Groups of Gansu Province 22JR5RA024Special Project of Gansu Province 22CX8NA011
6 · The paper itself

Abstract

African swine fever virus (ASFV) infection induces oxidative stress and produces oxidative DNA damage bases, leading to oxidative DNA base damage, including the formation of 8-oxoguanine (8-oxoG). Prompt repair of these lesions is essential to maintain genome stability. The enzyme 8-oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair (BER) pathway by recognizing and incising 8-oxoG, while also regulating multiple biological processes through interactions with host and viral proteins. In this study, we identified a specific interaction between the N-terminal region of ASFV DEAD-box helicase D1133L and OGG1, establishing a unique role for ASFV D1133L in DNA BER. Furthermore, we demonstrated for the first time that ASFV D1133L is a substrate for the histone acetyltransferases CBP/p300 in the nucleus. Conversely, deacetylation of D1133L by HDAC5, which predominantly occurs in the cytoplasm through its interaction with OGG1, markedly enhances OGG1 incision activity on 8-oxoG. Taken together, our findings reveal a previously unrecognized function of ASFV D1133L in promoting 8-oxoG repair by binding to OGG1 to safeguard genome integrity.

Indexed as

African Swine Fever VirusDNA GlycosylasesGuanineHistone DeacetylasesViral ProteinsAcetylationAnimalsDNA DamageDNA RepairHEK293 CellsHumansSwine8-hydroxyguanineDNA GlycosylasesGuanineHistone Deacetylasesoxoguanine glycosylase 1, humanViral Proteins8-oxoguanine DNA glycosylase 1acetylationAfrican swine fever virusD1133Lincision

Identifiers

PMID40862675
PMCPMC12902152

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.