Evidence map›Paper›PMID 40862610›Full record

ArticlemBio2025

Synergistic exacerbation of oral mucositis caused by IL-23 deficiency and oral

John T Dillon, Maura T Hickey, Jessica Saul-McBeth, Trevor Glanz, Yusuf Daboul, Yashwanth R Byreddy, Raymond Hohl, Jacqueline M Kratch, Jia A Thakker, Sarah L Gaffen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John T DillonDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Maura T HickeyDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Jessica Saul-McBethDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Trevor GlanzDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Yusuf DaboulDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Yashwanth R ByreddyDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Raymond HohlDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Jacqueline M KratchDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Jia A ThakkerDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.
Sarah L GaffenDepartment of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jacob GibbsDepartment of Radiation Oncology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.
Heather R ContiDepartment of Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, USA.ORCID 0000-0002-1491-4212

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
NIDCR NIH HHS DE022550NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R37 DE022550
6 · The paper itself

Abstract

Targeted head and neck irradiation (HNI) used for cancer therapy causes mucosal damage and immune dysregulation, leaving cancer patients highly susceptible to infections of the oral mucosa. Oropharyngeal candidiasis (OPC) is an opportunistic infection caused by

Indexed as

Candida albicansCandidiasis, OralInterleukin-23StomatitisAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutMouth MucosaTh17 CellsInterleukin-23candidiasishead-neck irradiationinterleukin-23irradiationoral mucositis

Identifiers

PMID40862610
PMCPMC12506028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.