Evidence map›Paper›PMID 40862607›Full record

ArticleJournal of bacteriology2025

Impact of protein prenylation inhibition on

Matheus da Silva Rocha, Antônio Marcos Rodrigues Pereira, Plínio Marcos Freire Dos Santos, André Alves Dias, Melissa Pontes Pereira, Patrícia Sammarco Rosa, Daniele F F Bertoluci, John T Belisle, Fabricio da Mota Ramalho Costa, Cristiana Santos de Macedo and 2 more

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. AMetabolites · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matheus da Silva RochaLaboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Antônio Marcos Rodrigues PereiraLaboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Plínio Marcos Freire Dos SantosLaboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
André Alves DiasLaboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Melissa Pontes PereiraLaboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Patrícia Sammarco RosaDivisão de Pesquisa e Ensino, Instituto Lauro de Souza Lima, São Paulo, Brazil.
Daniele F F BertoluciDivisão de Pesquisa e Ensino, Instituto Lauro de Souza Lima, São Paulo, Brazil.
John T BelisleDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Fabricio da Mota Ramalho CostaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Cristiana Santos de MacedoCenter for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.ORCID 0000-0002-5637-9756
Maria Cristina Vidal Pessolani *Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.ORCID 0000-0003-3064-8759
Marcia Berrêdo-Pinho *Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.ORCID 0000-0003-3598-1892

Funding

The Role of Schwann Cell Lipid Droplets In Neuropathology of LeprosyR01AI141526 · NIAID · COLORADO STATE UNIVERSITY · PI BELISLE, JOHN T, PESSOLANI, MARIA CRISTINA VIDAL · 2019 to 2023
$3.1M
Conselho Nacional de Desenvolvimento Científico e Tecnológico 432434/2018-6National Institute of Allergy and Infectious Diseases R01AI141526-01A1NIAID NIH HHS R01 AI141526
6 · The paper itself

Abstract

Leprosy is a chronic infectious disease caused by IMPORTANCE:

Indexed as

Interleukin-1betaMacrophagesMicrobial ViabilityMycobacterium lepraeProtein PrenylationAnimalsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLeprosyMevalonic AcidMicePolyisoprenyl PhosphatesSesquiterpenesfarnesyl pyrophosphategeranylgeranyl pyrophosphateHydroxymethylglutaryl-CoA Reductase InhibitorsInterleukin-1betaMevalonic AcidPolyisoprenyl PhosphatesSesquiterpenesIL-1βinflammasomeisoprenoidsleprosymevalonate pathwayprenylation

Identifiers

PMID40862607
PMCPMC12445085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.