Observational studyBrain and behavior2025
Sleep Disturbances Associated With Hidden Hearing Loss: Insights From Human Data and a Mouse Model of Sleep Fragmentation.
Observational study in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Hearing Loss as a Potentially Modifiable Marker of Dementia Risk: Neurological Evidence, Uncertainty, and Clinical Interpretation.Neuro-degenerative diseases · 2026Review
- Sleep Disturbances Associated With Hidden Hearing Loss: Insights From Human Data and a Mouse Model of Sleep Fragmentation.Brain and behavior · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundSleep disorders have been associated with auditory dysfunction. However, the specific effects of sleep fragmentation (SF) on the peripheral auditory system and the underlying mechanisms remain unclear.
methodsData from the National Health and Nutrition Examination Survey (NHANES) were analyzed to examine the association between sleep disturbances and difficulties in speech perception in noisy environments among participants with normal audiograms. Additionally, an SF mouse model was used to assess the impact of sleep disruption on auditory function and cochlear pathology. Auditory brainstem response (ABR) testing, immunofluorescence staining, and transmission electron microscopy were performed to evaluate the auditory system.
resultsNHANES data revealed that individuals with sleep disorders, even with normal audiograms, were more likely to experience difficulties in speech perception in noisy environments. In the mouse model, chronic SF led to a significant decrease in the amplitude and a prolonged latency of ABR wave I, without detectable changes in hearing thresholds. Immunofluorescence staining revealed a significant decrease in the number of ribbon synapses in inner hair cells and an increase in orphan ribbons. Moreover, electron microscopy demonstrated myelin damage in the auditory nerve fibers.
conclusionsSleep fragmentation induces subtle damage to the auditory system, particularly affecting inner hair cell synapses and auditory nerve fibers, which may underlie difficulties in speech recognition in noisy environments, a potential indicator of hidden hearing loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.