Evidence map›Paper›PMID 40862596›Full record

ArticleBrain and behavior2025

Do Hormonal Fluctuations in Healthy Women Influence the Somatosensory Temporal Discrimination Threshold?

Flavia Aiello, Maria Ilenia De Bartolo, Gina Ferrazzano, Giovanni De Fazio, Giovanni Fabbrini, Antonella Conte, Alfredo Berardelli, Daniele Belvisi

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Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Flavia AielloDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Maria Ilenia De BartoloDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Gina FerrazzanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Giovanni De FazioIRCCS Neuromed, Pozzilli (IS), Italy.
Giovanni FabbriniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Antonella ConteDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Alfredo BerardelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Daniele BelvisiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0009-0006-1275-2658

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreclinical studies and observations in human beings demonstrated that ovarian hormones exert complex, time-dependent effects on multiple brain regions, including those implicated in temporal sensory discrimination. The present study aims to investigate whether somatosensory temporal discrimination threshold (STDT) varies depending on the hormonal fluctuations in healthy women.

methodsTwenty-six young women were enrolled, of whom six were taking contraceptive therapy. In each subject, we assessed STDT, both by the step-wise measurement (sSTDT) and the randomized one (rSTDT), at the three main phases of the ovarian cycle: menstrual phase, ovulation, and the luteal phase.

resultsThe Friedman test did not reveal statistically significant differences among the three time points for either sSTDT (χ

conclusionsOur study did not reveal any hormone-dependent variations in STDT across the phases of the ovarian cycle, supporting the notion that STDT is a stable neurophysiological parameter.

Indexed as

Discrimination, PsychologicalMenstrual CycleSensory ThresholdsTime PerceptionTouch PerceptionAdultFemaleHumansYoung Adult

Identifiers

PMID40862596
PMCPMC12381957

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