ArticleBrain and behavior2025
Altered Basal Ganglia Network Topology Associated With Auditory-Motor Synchronization.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Coupling auditory cues and bilateral transauricular vagus nerve stimulation in Parkinson's disease with freezing of gait: an open-label feasibility study.Journal of rehabilitation medicine · 2026Article
- Can neurologic music therapy make the difference when using immersive virtual reality in Parkinson disease motor training? Promising findings from a secondary analysis.Frontiers in rehabilitation sciences · 2026Article
- Altered Basal Ganglia Network Topology Associated With Auditory-Motor Synchronization.Brain and behavior · 2025Article
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6 authors.
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Abstract
introductionAuditory-motor synchronization (AMS) embedded in Rhythmic Auditory Stimulation (RAS) is a validated method to improve gait, upper limb function, and motor speech in people with neurologic disorders like Parkinson's disease (PD). Predictable auditory cues optimize spatial movement patterns, and research has suggested that AMS reduces the brain's reliance on dopaminergic (DA) response in the ventral striatum. To gain a mechanistic understanding of the positive clinical outcomes related to AMS, this pilot study investigates the effects of AMS on the basal ganglia network (BGN) using brain network science methods.
methodsFourteen healthy adults (aged 22-37, seven females) completed two fMRI finger tapping tasks, a self-paced continuation (self) task and an auditory-motor synchronized (sync) task, both performed at 1 Hz. Using a modularity analysis of brain network data, we assessed the spatial consistency of the BGN. Additionally, we used a mixed-effects regression framework to test the hypotheses that changes in global and local efficiency are associated with the experimental tasks.
resultsThe spatial consistency of the BGN community was significantly greater in the sync task compared to the self task. Then, the regression model showed a significant change in the BGN's efficiency in the sync task over the self task. Specifically, the probability and the strength of connections between highly efficient nodes were significantly greater, indicating a more synchronized BGN.
conclusionAMS significantly changed the network topology of the BGN compared to no AMS. Specifically, the BGN became more functionally synchronized with AMS due to, mainly, greater network efficiency. These findings contribute to the growing mechanistic knowledge of how the BGN functional connections change with AMS and why AMS is a powerful tool to treat neurologic disorders such as PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.